Abstract 47P
Background
Adrenocortical carcinoma (ACC) patients' quality of life may be impacted by symptoms related to cancer or treatments, as well as emotional, spiritual, existential, social, economic, and sexual aspects. The aim of our project was the development and psychometric validation of a new instrument (QoLACC) for measuring Patient Reported Outcome in patients with ACC.
Methods
Comprehensibility, difficulty and clinical relevance of the items to include in the QoLACC questionnaire were assessed by selected ACC patients and clinicians of the Oncology Unit of Brescia’s ASST Spedali Civili. Validated scales were co-administered to the developed QoLACC questionnaire to assess physical and psychological symptoms, and the test-retest reliability and construct validity psychometric validation were performed.
Results
Fifteen patients and 15 physicians graded the comprehensibility/difficulty and relevance of the items of QoLACC whereas 37 consecutive patients assessed psychometric validity. The QoLACC items showed excellent content validity [0.93-1.00] and acceptable to excellent comprehensibility [0.80-1.00] and difficulty [0.80-1.00], with minor exceptions. Item analysis showed good discriminant capability and response variability. The total questionnaire has good reliability (the intraclass correlation coefficient (ICC) was 0.870 [95% CI: 0.734-0.937]) and construct validity proved by the moderate to strong correlations [0.39-0.62] between the QoLACC and the EORTC item 29 and item 30, the QoLACC financial section and the COST (0.47), and the QoLACC spiritual section and the JSWBS (0.60).
Conclusions
We defined and validated the Italian questionnaire aiming to explore ACC patients’ quality of life, in order to help the Health Care Professionals to manage and support these patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.