Abstract 130P
Background
Head and neck soft tissue sarcomas (HNSTS) are a group of rare heterogeneous tumours arising from embryonic mesoderm. They comprise <1% of all head and neck malignancies and 5–15% of all sarcomas with most head and neck sarcomas arising from soft tissues. As a result, the prognostic determinants of this disease have not yet been fully elucidated. This study aimed to examine the prognostic indicators and oncological outcomes associated with HNSTS.
Methods
Between 2014 and 20019, the medical records of 51 adult patients were retrospectively evaluated. Potential prognostic factors were analyzed in relation to overall survival (OS) and disease-free survival (DFS). Univariate and multivariate analyses were conducted using the Cox proportional hazards model to identify clinicopathologic factors associated with DFS and OS.
Results
Rhabdomyosarcoma was the most prevalent tumor type (24%), followed by angiosarcoma (14%). The majority of the patients received treatment with the doxorubicin and ifosfamide protocol. At 5 years, OS was 69%, and DFS was 59%. Univariate analysis revealed that distant or lymph node metastasis at diagnosis, surgical margins, and overall stage were statistically significant prognostic factors for both OS and DFS. Multivariate analysis demonstrated that surgical margins remained a statistically significant factor for DFS, while overall stage remained significant for OS.
Conclusions
This comprehensive analysis establishes surgical margins and overall stage as independent prognostic factors in head and neck soft tissue sarcomas. The findings demonstrate favorable long-term survival outcomes, with 5-year overall survival reaching 69%. These results strongly support the critical importance of achieving clear surgical margins and emphasize the necessity of accurate staging in treatment planning. This evidence provides a robust foundation for clinical decision-making in managing these rare but challenging neoplasms.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
M.M. Kidi.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.