Abstract 13P
Background
To evaluate the risk stratification by HPV-integration levels and HPV integration status conversion in HPV integration-positive women after 1-year follow-up.
Methods
This prospective cohort study conducted in Tongji hospital between June 2020 to August 2022 with 1297 consecutive HPV-positive women. The level of integration reads was stratified for risk assessment.
Results
A total of 194 women were HPV integration-positive and followed-up for at least 1 year. The immediate risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) increased from 36.2% (25/69) in women with 6-20 integration reads to 93.8% (30/32) in women with more than 1000 integration reads (Ptrend < 0.001). The 1-year cumulative risk of CIN2+ increased from 39.1% (27/64) in women with 6-20 integration reads to 96.9% (31/32) in women with more than 1000 integration reads (Ptrend < 0.001). The 1-year cumulative risk of CIN2+ with HPV integration reads more than 40 was 93.8% (90/96), which was significantly higher than that of HPV integration reads less than 40 (38/85, P < 0.001). At one-year follow-up, in women with HPV integration reads more than 40, 99.0% (95/96) of women progressed with positive outcomes (persistent integration at the same site, immediate CIN2+ and 1-year CIN2+). The progression rate of women with persistent integration at the same site was 41.6% (5/12), which was significantly higher than those of HPV-integration negative conversion (0/41, 0%, P < 0.001).
Conclusions
The number of HPV integration reads may have the potential in CIN2+ risk stratification to facilitate the clinical management of high-risk patients.
Legal entity responsible for the study
The authors.
Funding
The National Key R&D Program of China.
Disclosure
All authors have declared no conflicts of interest.