Abstract 50P
Background
Despite considerable efforts, little advances have been made in the treatment of platinum resistant ovarian cancer (PROC) in the last decade. The reasons for these dismal results remain controversial. Understanding phase (Ph) 3 randomized controlled trials (RCT) design and outcomes in PROC patients might provide indications for the development of future research.
Methods
We performed a systematic review searching in PubMed, Embase and CENTRAL for Ph3 RCT enrolling PROC patients, published between 2010 and 2022. For the meta-analysis, effect sizes (ES) for progression free survival (PFS) and overall survival (OS) were calculated using random-effect models with restricted maximum likelihood estimate.
Results
After screening and eligibility assessment, 15 records reporting the results of 13 RCT were included, for a total of 4606 patients. Experimental arm employed targeted agents in 6 trials, chemotherapy (Cht) in 4, immunotherapy in 2 and antibody-drug conjugate in 1. Control treatment was Cht in all studies. Only 3 trials included a biomarker-selected population. PFS and/or OS were the (co-)primary endpoints in all studies but one. Median PFS ranged from 1.9 to 6.7 months (m) in the experimental arms and from 1.2 to 5.7 m in the control arms; median OS ranged from 8.8 to 16.6 m in experimental arms and from 8.4 to 22.2 m in the control arms. All but two trials (TRINOVA1 and AURELIA) failed to show any PFS benefit in PROC patients and none had positive OS results. Overall ES for PFS was -0.03 (95% CI -0.23, 0.16), with high heterogeneity (I283.3%) while ES for OS was -0.02 (95% CI -0.10, 0.05) with negligible heterogeneity (I2<0.0001). Of the included Ph3 RCT, 6 were preceded by a single arm and 3 by a randomized Ph2 study.
Conclusions
The two RCT testing the anti-angiogenic agents bevacizumab and trebananib combined with Cht were the only reporting a PFS benefit in PROC. The lack of robust predictive biomarkers, of adequate preclinical and early clinical results and of a proper methodology might partly explain these disappointing outcomes. A better understanding of PROC biology and its implementation in study design are crucial to improve drug development in this population.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
F. Martorana: Non-Financial Interests, Personal, Other, travel grant: Roche, Gilead; Financial Interests, Personal, Invited Speaker: Pfizer, Novartis, Lilly, Istituto Gentili; Financial Interests, Personal, Advisory Board: Amgen. C. Sessa: Non-Financial Interests, Personal, Other, Coordinator Gynecological Programme: ESO; Non-Financial Interests, Personal, Advisory Role, ESMO extended member women for oncology: ESMO; Non-Financial Interests, Personal, Advisory Role, Member of the compliance committee: ESMO; Non-Financial Interests, Personal, Leadership Role, editor of living clinical practice guidelines: ESMO; Non-Financial Interests, Personal, Advisory Role, Medical advisor for innovation, institutional interest: Swiss Group for Clinical Cancer Research (SAKK). S. Lheureux: Financial Interests, Personal, Advisory Board: AstraZeneca, GSK, Eisai, Merck, Novartis; Financial Interests, Personal, Invited Speaker: GSK, Roche; Financial Interests, Institutional, Research Grant, Academic trial: GSK; Financial Interests, Institutional, Invited Speaker: Repare Therapeutics, Merck, AstraZeneca, Regeneron, GSK, Roche, Seagen; Financial Interests, Institutional, Research Grant: Roche. I. Colombo: Financial Interests, Personal, Expert Testimony: AstraZeneca, GSK; Financial Interests, Personal, Other, Travel grants: Tesaro; Financial Interests, Institutional, Expert Testimony: AstraZeneca; Financial Interests, Institutional, Advisory Board: GSK; Financial Interests, Personal, Advisory Board: MSD; Financial Interests, Personal, Full or part-time Employment, My husband was a Medtronic employee until 04.2020: Medtronic; Financial Interests, Personal, Full or part-time Employment, Employee since 02.2022: Medtronic; Financial Interests, Personal, Stocks/Shares: Medtronic; Financial Interests, Institutional, Invited Speaker: MSD, Bayer, Oasmia; Non-Financial Interests, Personal, Leadership Role: Swiss Group for Clinical Cancer Research (SAKK).