Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

EONS Poster Display session

CN44 - Genetic associations between pan-cancer and phenotype of COVID-19: A bidirectional Bayesian Weighted Mendelian randomization study

Date

15 Sep 2024

Session

EONS Poster Display session

Topics

Translational Research;  Cancer in Special Situations/ Populations

Tumour Site

Presenters

Yaxin Kang

Citation

Annals of Oncology (2024) 35 (suppl_2): S1179-S1184. 10.1016/annonc/annonc1582

Authors

Y. Kang1, Q. Xu2, J. Liu3, L. Li3, F. Zhu1

Author affiliations

  • 1 Gynecology Department, Fujian Provincial Cancer Hospital, 350014 - Fuzhou/CN
  • 2 Department Of Gynaecology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, 350014 - Fuzhou/CN
  • 3 Gynecologic Radiotherapy, Fujian Provincial Cancer Hospital, 350014 - Fuzhou/CN

Resources

Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract CN44

Background

Previous studies had taken attention to the association between coronavirus disease-2019 (COVID-19) and cancer risk. However, they usually focused on single population such as European.

Methods

We used bidirectional Mendelian randomization (MR) and Bayesian weighted MR (BWMR) to explore the causal associations between the 25 types of COVID-19 exposures of different regions and 33 different types of cancers of the European population. To assess horizontal pleiotropy, we employed MR-Egger regression and MR-PRESSO global tests, with the Cochrane Q-test utilized to measure the presence of heterogeneity.

Results

We found malignant neoplasm of bladder, malignant neoplasm of thyroid gland, and neuroendocrine tumor and carcinoma of lung were associated with the increased risk of critically ill COVID-19 in African, while, malignant neoplasm of esophagus had negative impact. For the east Asian, we found malignant neoplasm of bronchus and lung was associated with the decreased risk. Malignant neoplasm of breast had positive impact on critically ill COVID-19 in European and malignant neoplasm of testis had a negative. Increased risk of hospitalized COVID-19 (hospitalized vs not hospitalized) was associated with malignant neoplasm of skin. Meanwhile, malignant neoplasm of brain, small and non−small cell lung cancer, malignant melanoma, malignant neoplasm of oral cavity, malignant neoplasm of prostate, mature T/NK−cell lymphomas and malignant neoplasm of ovary were linked to the increased risk of diverse adverse response of BNT162b2 vaccine (malignant neoplasm of brain had negative impact on nausea). While, malignant neoplasm of pancreas, malignant neoplasm of testis, and malignant neoplasm of stomach were associated with decreased risk.

Conclusions

Together, we found the association of 19 types of cancers and 15 phenotypes of COVID-19 linked to susceptibility, severity, hospitalization, vaccination efficacy and vaccination safety.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Q. Xu.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.