1682P - Assessment of health-related quality of life, psychosocial distress and financial toxicity among prostate cancer patients in luth: A cross-sectional survey in south-west Nigeria

Background

Prostate cancer (PC) presents a significant health challenge in Africa, especially in regions like Nigeria with limited access to care. Despite medical advancements, PC treatment affects patients beyond their physical health, impacting their quality of life (QoL) and financial toxicity (FT) due to high treatment costs and inadequate insurance coverage. Patient-reported outcomes are often overlooked in African PC research, creating knowledge gaps that need to be addressed.

Methods

This descriptive cross-sectional study aimed to assess patient-reported outcomes among male PC patients at Lagos University Teaching Hospital (LUTH) and the NSIA-LUTH Cancer Centre (NLCC). Data collection involved interviewer-based structured questionnaires that inculcated QoL (FACT-P), psychosocial distress (PHQ-4), and FT (FACIT-COST). Analysis was done with RStudio, with a P-value set at <0.05 for statistical significance. Ethical approval was obtained.

Results

This study examined 200 prostate cancer patients at LUTH. Participants were primarily aged 61–70; most are married with tertiary education, and the majority are retired. Comorbidities, particularly hypertension (32.0%) and diabetes mellitus (22.5%), are prevalent. Notable findings include the impact of age, employment status, and comorbidities on QoL and FT. ECOG scores, cancer stage, and comorbidities significantly influence psychological distress levels. Associations between QoL, financial toxicity, and psychosocial distress underscore the complex interplay between these factors. No significant link was found between QoL and FT.

Conclusions

This study sheds light on the challenges faced by PC patients at LUTH, highlighting the complex interplay of factors. Economic challenges included limited health insurance coverage and financial strain. Early detection and intervention are crucial, given the distribution of cancer stages and the prevalence of comorbidities among patients. FT emerges as a significant issue, impacting patients' QoL and psychosocial well-being. The lack of significant associations with health insurance coverage suggests the need for comprehensive healthcare reforms.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

R. O. Jimoh.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.