Abstract 834P
Background
Marginal zone lymphoma (MZL) is a relatively common group of inert B-cell non-Hodgkin’s lymphoma (B-NHL) originating from peripheral memory lymphocytes. Some patients cannot achieve complete remission or relapse quickly after standard first-line treatment. Studies have shown that the NF-KB signal pathway in MZL is in an abnormally activated state, while bortezomib is a proteasome inhibitor targeting the NF-KB pathway. This multicenter phase II clinical study evaluated the efficacy and safety of VR-CAP regimen in the first-line treatment of MZL, and explored the best beneficiaries of VR-CAP regimen (rituximab, cyclophosphamide, epirubicin, bortezomib and prednisone).
Methods
The patient received 6 cycles of VR-CAP first-line treatment. Each cycle lasts for 3 weeks, and rituximab (375 mg/m2) is given intravenously on the 0th day, cyclophosphamide (750 mg/m2) and epirubicin (70 mg/m2) are given intravenously on the 1st day, bortezomib (1.3 mg/m2) is given subcutaneously on the 1st and 4th days, and prednisone (100 mg) is given orally on the 1st to 5th days. The primary end point was 2-year progression-free survival (PFS), and the secondary end point was objective response rate (ORR), including complete response (CR) and partial response (PR); Total survival (OS) and security.
Results
At present, 23 patients were enrolled, the median age was 55 years (25-74 years). By February 2023, 15 patients had completed all six courses of treatment; 6 patients completed 4 courses of treatment; Two patients stopped treatment by themselves, and 22 patients could evaluate the curative effect. Sixteen patients (72.7%) and five patients (22.7%) achieved CR/CRu and PR respectively. PFS and OS were 82.2% and 82.0% respectively in two years. Among the 13 patients who have completed all the treatment, the common therapeutic adverse events are anemia (73.9%), gastrointestinal reaction (52.2%), thrombocytopenia (30.4%), pulmonary infection (21.7%), neurotoxicity (8.7%), rituximab-related rash (8.7%).
Conclusions
VR-CAP first-line treatment of lymphoma in the marginal region has a good effect, the objective response rate (ORR) is 95.5%, and the patient is well tolerated. All adverse events are mainly 1-2 grades.
Clinical trial identification
NCT04433156.
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
832P - Characterisation of EXS73565: A potent and selective MALT1 inhibitor with low drug-drug interaction risk and potential in lymphoma
Presenter: Major Gooyit
Session: Poster session 18
833P - New targets for adult T cell leukemia/lymphoma (ATLL): A map for ATLL immunotherapy
Presenter: Zahra Rezaei Borojerdi
Session: Poster session 18
835P - A safe and effective immunochemotherapy with oral sobuzoxane and etoposide for untreated diffuse large B cell lymphoma patients aged 80 and over
Presenter: Kaname Miyashita
Session: Poster session 18
838P - Matching-adjusted indirect comparison (MAIC) of axicabtagene ciloleucel (axi-cel) and epcoritamab (epcor) in relapsed/refractory (R/R) large B cell lymphoma (LBCL) after at least two prior systemic therapies (3L+)
Presenter: Olalekan Oluwole
Session: Poster session 18
840P - Genomic landscape, immune characteristics and prognostic mutation signature of extranodal NK/T cell lymphoma, nasal type in China
Presenter: Yue Chai
Session: Poster session 18
841P - Ki67-revised risk index to risk-stratify patients with extra-nodal natural killer/T cell lymphoma
Presenter: Shuo Li
Session: Poster session 18
842P - Multicenter real-world study of newly diagnosed advanced-stage extranodal natural killer/T cell lymphoma (ENKTL): Proposal for intensive therapy
Presenter: Yu-Ce Wei
Session: Poster session 18