Abstract 833P
Background
In this study, we summarize the chemokines that are involved in malignant HTLV-1 associated disease, adult T cell leukemia/lymphoma (ATLL) progression. The interaction of virus and host were evaluated in chemokine level.
Methods
The expression of CCR6, CXCR-3, the HTLV-1 proviral load (PVL), HTLV-1-Tax, and HBZ were assessed in 12 asymptomatic HTLV-1carriers (ACs), 12 healthy controls (HCs) and 12 ATLL patients. We applied quantitative real-time PCR (qRT-PCR) and TaqMan method.
Results
As per results, the level of CXCR3 gene expression in ATLL patients compared to HTLV-1 virus carriers and healthy people showed a significant difference (P=0.00 and P=0.008). Also, the mean expression of CCR6 genes in ATLL patients compared to HTLV-1 virus carriers had a significant difference of P=0.04, but in the ATLL group there was no significant difference compare to the healthy group.
Conclusions
Our study results illustrate that the expression of chemokine receptors is directly related to the course and stages of the disease as well as the prognosis of the disease. In carriers, compared to healthy individuals, we still have a higher level of expression of chemokine. In addition with the progression of the conflict and the progression to malignancy and involvement of T lymphocytes (the producer of these chemokines) as shown in our study, we can conclude that with decreased levels of these chemokine receptors can lead to malignancy with a poor prognosis. Our findings confirms previous studies that Tax protein may not be expressed in ATLL patients. Additionally an oncoprotein may involve in inducing malignancy, but in the absence of Tax, HTLV-1-HBZ protein implicated in the maintenance of mechanism of the virus to escape from the host cell immune system. We also found an increase in virus load as HTLV-1 carriers move toward. So these chemokines could be suggested as influential targets for the prognosis and proper therapy of ATLL.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
990P - Prognosis prediction for unresectable hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy using convolutional neural network model
Presenter: bing quan
Session: Poster session 18
991P - Real-world comparison of trans-arterial chemoembolization and bland embolization for the treatment of hepatocellular carcinoma: A propensity score analysis
Presenter: Allan Ramos-Esquivel
Session: Poster session 18
993P - Thyroid dysfunction after atezolizumab and bevacizumab is associated with favorable outcomes in hepatocellular carcinoma (IMbrave150 and Korean patients cohorts)
Presenter: Hongjae Chon
Session: Poster session 18
995P - Real-world treatment patterns, survival and costs in advanced hepatocellular carcinoma (aHCC) in Ontario, Canada
Presenter: Dominick Bossé
Session: Poster session 18
996P - Transarterial chemoembolization combined donafenib with/without programmed death-1 inhibitors for initially unresectable hepatocellular carcinoma in a multicenter retrospective study
Presenter: Xuhua Duan
Session: Poster session 18
998P - Efficacy and safety of curative hepatectomy after conversion therapies for initial unresectable hepatocellular carcinoma: A multicenter propensity score matching study
Presenter: Rong-yun Mai
Session: Poster session 18