Abstract 2135P
Background
G8 and GA assessments to screen for frailty and facilitate appropriate interventions have been recommended by the International Society for Geriatric Oncology in older adults with cancer. The main objective of this study is to evaluate the impact of G8 and GA-based interventions on the QoL of older Asian adults with cancer.
Methods
This is a prospective study of cancer patients aged ≥70 treated at the National University Cancer Institute, Singapore. The G8, CGA, and EORTC QLQ 30 questionnaires were administered at study entry. Targeted interventions were offered by the multi-disciplinary geriatric oncology (GO) service. After three months, a follow-up EORTC QLQ 30 was repeated for those who required geriatric interventions. Primary outcome measure was comparison of pre/post- EORTC QLQ 30 scores.
Results
N=230 patients were accrued. Median age was 74 (range:70-90). Majority were male (56%), diagnosed with gastrointestinal cancers (35%) and receiving palliative intent treatment (60%). Based on GA, 11% were classified as frail, 58% as pre-frail and 31% as fit. 79% had G8 scores ≤14. Pre-frail, frail and those with G8 ≤14 had lower baseline EORTC QOL function scores and higher EORTC QOL symptom scores (p<0.05). They also had significantly shorter overall survival (OS) compared to fit or with patients G8>14. (HR=2.54 95% CI 1.46-4.43, p=0.001 for frail vs fit patients; HR=1.72 95% CI 1.18-2.53, p=0.005 for pre-frail vs fit patients; HR=1.51 95% CI 1.05-2.18, p=0.027 for G8 ≤14 vs >14). GO interventions were suggested for 144 patients with 104 patients completing a 2nd EORTC QOL questionnaire. These patients reported significant improvements in the EORTC emotional and social functioning domains (mean difference +4.6, p<0.001 and +12.3 p<0.001, respectively), a significant reduction in the EORTC symptom scale of pain, insomnia, constipation, and financial difficulties (mean difference -5.8 p=0.003, -8.3 p<0.001, -9.0 p<0.001, and -6 p=0.01), with no significant deterioration in other QOL domains.
Conclusions
Geriatric assessment-based targeted interventions delivered by a multidisciplinary GO service significantly improved multiple QOL domains in older Asian adults undergoing cancer treatment.
Clinical trial identification
DSRB Study Reference Number: 2017/00214.
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Singapore Cancer Society.
Disclosure
C.E. Chee: Financial Interests, Institutional, Advisory Board: Merck, AstraZeneca, Roche. All other authors have declared no conflicts of interest.
Resources from the same session
2130P - ATTITUDE - ATTrition In longiTUDinal studiEs of cancer survivors (CS): Can we improve the experience of patients (pts)?
Presenter: Camila Chiodi
Session: Poster session 07
2131P - Real-life experiences from a late effects clinic: An investigation of health-related quality of life in Danish cancer survivors
Presenter: Lærke Tolstrup
Session: Poster session 07
2132P - Unmet needs, quality of life, and financial toxicity in survivors of lung cancer
Presenter: Josephine Feliciano
Session: Poster session 07
2133P - Sleep disorders: Evolution in time in early breast cancer (EBC)
Presenter: Blanca Cantos
Session: Poster session 07
2134P - Self-reported late effects, need for information and follow-up in long-term Hodgkin lymphoma survivors
Presenter: Lise Willumsen
Session: Poster session 07
2136P - Prostate cancer supportive care (PCSC) program for patients and partners: A model for meeting an unmet need for PC patients
Presenter: Celestia Higano
Session: Poster session 07
2137P - Impact of supportive care on the quality of life (QoL) of hospitalized cancer patients (pts)
Presenter: Judit Sanz Beltran
Session: Poster session 07
2138P - Time toxicity of palliative chemotherapy in a geriatric oncology population
Presenter: Christopher Cronin
Session: Poster session 07
2139P - Quality of life in adult cancer survivors (QLACS) in Spain: Study of its clinical characteristics and use of social media for oncological information
Presenter: Maria Cornide Santos
Session: Poster session 07
2140P - Short-term quality-of-life after metastases-directed SBRT: Results of the prospective ESTRO & EORTC OligoCare cohort
Presenter: Daniela Greto
Session: Poster session 07