Abstract 511P
Background
Disruption of the immune system is known to favor carcinogenesis and cancer breakthrough. Gliomas constitute de most prevalent primary malignant brain tumors. We aimed to study the occurrence of immune disruptive conditions (IDC) in patients with gliomas at our institution.
Methods
Retrospective study of patients (pts) diagnosed with a glioma at Hospital Clínico Universitario San Carlos, Madrid (Spain). IDCs included autoimmune diseases (AID), organ transplantation (OT) requiring chronic immunosuppressive therapy (IST), and hematological malignancies (HM). A descriptive study, as well as time since IDC, time under IST, and progression-free survival (PFS) and overall survival (OS) since glioma diagnosis were analyzed.
Results
Within the period January 1999 – April 2023, among 481 patients diagnosed with a glioma, 30 (6.2%) patients harbored IDCs. Male/Female: 14/16. Age: 63y (32-83). WHO 5th Ed.: IDH-WT GB: n=26 (MGMTmeth: 50%, MGMTunmeth: 50%), IDH-MUT Astro: n=3, Pleomorphic xanthoastro: n=1. Frontal: n=14, Temporal: n=8, Parietal: n=6. Unilobar: n=23, Bilobar: n=4, Trilobar: n=1. Right: n=8, Left: n=19, Bilateral: n=3. Resection: GTR=8, STR=1, Partial=3, Biopsy=14. RTx=20 pts, CRTx=18, Adj CTx=13. Median PFS and OS since diax were 9 and 10 months (m), respectively. No. of IDCs: 1 (n=21 pts), ≥ 2 (n=9 pts). IDC type: AID (n=27 pts) among which: endocrine (4: Addison, Hypothyroidism, Hashimoto's thyroiditis), respiratory (7: asthma, sarcoidosis, alergic rinoconjunctivitis), cutaneous (7: chronic eccema, psoriasis), neurological (4: multiple sclerosis, Guillain-Barré), digestive system (2: inflammatory bowel disease), rheumatological (13: Horton's disease, Sjöegren's syndrome, systemic lupus erithematosus, uveitis, vasculitis); HM (1: chronic lymphocytic leukaemia); OT (2: renal). IST for IDCs used in 20 pts (systemic IST in 17). Median time since IDC: 101 m (10-411). Median time under IST: 108 m (0-283).
Conclusions
Within a large 24-year long retrospective series, a minority of pts with glioma harbored an IDC, most commonly rheumatological, respiratory, or cutaneous. Studies should be conducted to unveil if gliomas occurring in pts with IDCs are biologically and immunologically distinct.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
S. Cabezas-Camarero: Financial Interests, Personal, Invited Speaker: MSD, Bristol Myers Squibb, Janssen; Non-Financial Interests, Personal, Funding, Research project Head and Neck Cancer: Merck KgGa; Other, Personal, Other, Travel arrangement: Merck KgGa; Other, Personal, Other, Travel arrangements: Janssen. All other authors have declared no conflicts of interest.
Resources from the same session
88P - PPM1D/WIP1 phosphatase mediates basal and genotoxic stress-induced autophagy via ULK-1 de-phosphorylation
Presenter: Ceylan Ak
Session: Poster session 09
89P - Cold atmospheric plasma-activated fluids as a potential new intravesical agent for the treatment of bladder cancer
Presenter: Maria Filomena Botelho
Session: Poster session 09
90P - Discovery of CMPD1 as a tumor-specific cytotoxic microtubule inhibitor
Presenter: Mamoru Takada
Session: Poster session 09
91P - Erythroid precursor-differentiated myeloid cells promote pulmonary metastasis in hepatocellular carcinoma
Presenter: Wei-hang Zhu
Session: Poster session 09
92P - Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs
Presenter: Hsing-Pang Hsieh
Session: Poster session 09
93P - Transcriptome changes of immune cells across chemotherapy of triple-negative breast cancer
Presenter: Tatiana Gerashchenko
Session: Poster session 09
509P - Spatial analysis of tumor-associated macrophages within the tumor microenvironment of primary tumors and matched brain metastases
Presenter: Markus Kleinberger
Session: Poster session 09
510P - CD47 regulates cellular and metabolic plasticity in glioblastoma
Presenter: Ruhi Polara
Session: Poster session 09
512P - Heterozygous germline Fanconi anemia-related gene mutations increase susceptibility to central nervous system germ cell tumors
Presenter: Guangyu Wang
Session: Poster session 09
513P - Cyclin pathway in oligodendrogliomas IDH mut and 1p/19q codeleted
Presenter: Maria Angeles Vaz Salgado
Session: Poster session 09