2347P - Correlation between second primary cancers and first primary cancers: A systematic review and meta-analysis of 9 million cancer patients

Background

Many survivors of first primary cancers (FPCs) are at risk of developing a second primary cancer (SPC), the development of which usually leads to a worse prognosis. The development of SPCs may be closely related to the FPC. Different primary cancers have differentially high frequencies of specific SPC development. Our aim was to explore the possible correlation between the SPCs and FPCs.

Methods

We retrospectively searched and screened relevant literature on SPCs from four databases, namely, PubMed, EMBASE, Web of Science, and PMC. We also collected data on 28 different organ sites and the number of patients with SPC from The Surveillance, Epidemiology, and End Results (SEER) 8 Registry Database and NHANES database.

Results

A total of 9,617,643 patients with a FPC and 677,430 patients with a SPC were included in this meta-analysis. Patients with first primary gynaecological cancer and thyroid cancer developed second primary breast cancer and colorectal cancer more frequently. Patients with first primary head and neck cancer, anal cancer and esophageal cancer developed second primary lung cancer more frequently. Patients with first primary bladder cancer and penile cancer developed second primary lung cancer and prostate cancer more frequently. Patients with second primary bladder cancer accounted for 56% of first primary ureteral cancer patients with SPCs.

Conclusions

We recommend close clinical follow-up, monitoring and appropriate interventions in patients with relevant FPCs for better screening and early diagnosis of SPCs to prolong patient survival.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Peng Luo.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.