128P - Biliary tract cancers: Epidemiological and prognosis trends of Latin American population

Background

Biliary tract cancers are heterogeneous tumors defined by the anatomical location, intrahepatic, cholangiocarcinoma (ICC), extrahepatic (ECC), gallbladder and ampulla of Vater cancer (AVC).The outcome of treatment by location remains unclear in Latin American population, resulting in inconsistently data to enhance treatment decisions and outcome. The aim of this study is to describe the epidemiological features and prognosis of overall survival of Latin American population with biliary tract cancers.

Methods

Retrospective, observational study. Included patients treated at the National Cancer Institute between 2008 and 2022. Statistical analysis required: X² and t test, Kaplan Meier, Log Rank and Cox Regression. Statistical significance differences were assessed when p was bilaterally <0.05.

Results

A total 786 of patients diagnosed with biliary tract cancer were included in the analysis. Patients had a median age of 61 years (24-96). Alcohol consumption and smoking were observed in 22% and 29% respectively. Regarding comorbidities, 22% had Type2DM, 27% HAS, and obesity & overweight was present in 13% and 32% respectively. Anatomical location included ICC (19%;n=151), ECC (22%;n=172), gallbladder (33%;n=259) and AVC (26%;n=204). Female were more prevalent in gallbladder and ICC (79% & 71%) (p<0.001). Median time to diagnosis was 3 months (0–120); extent of disease was observed as localized (18%;n=144), local-advanced (20%;n=158), and metastatic (60%;n=472). In metastatic patients, mean number of metastasis was 1 (1-7), being liver (66%), retroperitoneum (7%), and lung (6%) the most frequent sites. Comparing Chemotherapy and extent of disesase, 35%, 53%, and 55% patients received treatment for localized, unresectable, and metastatic (p=0.001). An OS analysis was conducted considering location, ICC patients showed a median-OS of 9months, ECC a median-OS of 12months, gallbladder a median-OS of 1months and AVC did not reach median-OS (p<0.001).

Conclusions

Prognosis and outcome for patients with biliary tract cancer differ depending on the anatomical subsite. This is one of the main studies describing epidemiological features, and outcome in Latin American patients with biliary tract.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.