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Poster session 02

188P - Characteristics of second primary breast cancer after ovarian cancer: A Korea central cancer registry retrospective study

Date

10 Sep 2022

Session

Poster session 02

Topics

Tumour Site

Breast Cancer

Presenters

Eun-Gyeong Lee

Citation

Annals of Oncology (2022) 33 (suppl_7): S55-S84. 10.1016/annonc/annonc1038

Authors

E. Lee1, S. Jung2, Y. Won3, J. Lim4, H.I. Ha5, M. Lim6, Y.J. Chang7

Author affiliations

  • 1 Center For Breast Cancer, NCC - National Cancer Center, 10408 - Goyang/KR
  • 2 Center For Breast Cancer, National Cancer Center, 410-769 - Goyang/KR
  • 3 Division Of Health Administration, Yonsei University, 26493 - Wonju/KR
  • 4 Cancer Registration And Statistic Branch, NCC-National Cancer Center, 10408 - Goyang/KR
  • 5 Department Of Obstetrics And Gynecology, Pusan National University Yangsan Hospital, 626-770 - Yangsan/KR
  • 6 Center For Uterine Cancer And Department Of Cancer Healthcare Research, National Cancer Center - Graduate School of Cancer Science and Policy, 10408 - Goyang/KR
  • 7 Department Of Cancer And Population Health, NCC - National Cancer Center, 10408 - Goyang/KR

Resources

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Abstract 188P

Background

Second primary cancer has become an important issue among cancer survivors. This study sought to determine the differences in clinicopathologic outcomes between second primary breast cancer (SPBC) after ovarian cancer and primary breast cancer (PBC) in Korea.

Methods

We searched the Korea Central Cancer Registry and identified 251,244 breast cancer cases that were diagnosed between 1999 and 2017. Demographic and clinical characteristics and overall survival (OS) rates were estimated according to age, histological type, and cancer stage.

Results

Among the 228,329 patients included, 228,148 were patients with PBC and 181 were had SPBC, diagnosed after ovarian cancer (OC). Based on the age-standardized rate (ASR), the incidence of SPBC after OC was 293.58 per 100,000 ovarian patients and the incidence of PBC was 39.13 per 100,000 women. The 5-year OS rates were 72.88% and 89.37% for SPBC and PBC (p < 0.0001). The most common ages at diagnosis were 50‒59 years for SPBC and 40–49 years for PBC. Patients with SPBC were significantly less likely than patients with PBC to receive adjuvant radiotherapy (14.92% vs. 21.92%, p = 0.0228) or adjuvant chemotherapy (44.75% vs. 55.69%, p = 0.0031). The OS rate in SPBC decreased significantly with advanced stage and older age.

Conclusions

The incidence of breast cancer is about 1.27 times higher in ovarian cancer patients than in healthy people. The survival outcomes were worse for SPBC than for PBC and were related to older age and advanced stage. Active screening for breast cancer is necessary in ovarian cancer patients.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

National Cancer Center.

Disclosure

All authors have declared no conflicts of interest.

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