Abstract CN18
Background
In Mexico genetic counseling is given by medical geneticists, the access is scarce added to socioeconomic characteristics of the population, reaching a definitive diagnosis in hereditary cancer syndromes is difficult. Therefore is underdiagnosed. The CUCC (Centro Universitario Contra el Cáncer) Early Cancer Detection Clinic (CECIL) create a model in which open population could enroll in a prevention cancer screening program.
Methods
From 2016-2021 a total of 3014 patients were enrolled. Patients were first filtered with a risk questionnaire prior consultation, those with at least one positive answer were selected to a genetic evaluation, and a second filter was made by the general physician. Also all patients referred from oncology consultation were evaluated. Those who fulfill hereditary cancer criteria were offered a genetic testing. Resources for the testing were obtained by patient pay, foundations, donations and research protocols.
Results
A total of 1119 subjects were evaluated. Of these 248 (21%) were candidates to genetic testing, only 149 (60%) could be analyzed, 52 probands (59%) and 32 relatives (51%) had at least one variant. Among the probands: 33 had HBOC (Hereditary Breast and Ovarian Cancer syndrome), 7 had Lynch, 1 LFS (Li-Fraumeni syndrome), 1 LFLS (Li-Fraumeni like syndrome), 1 FAP (Familial Adenomatous Polyposis), and 9 had benign variants. In the relatives group: 17 had Lynch, 10 HBOC, 1 LFS, and 4 FAP. To date 3 patients under surveillance had an in situ lesion, (1 endometrial and 2 colon), and 3 more had a premalignant colon lesion, one in the not tested group. To achieve low cost testing, 50%probands had partial sponsored, 31% patient paid, 13% by research and 4.5% by donations. Among relatives 94.4% were patient paid, and 5.5% by research, all relative were in-house low cost test.
Conclusions
The success of the model made awareness of these diseases, leading last year to the formation of a state detection program; including all public and private health institution with an oncology service refer their patients to this center. Also to found rising and agreements with laboratories to offer low cost genetic testing.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Unviersidad Autonoma de Nuevo León.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.