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ePoster Display

1347P - Real-life patient management patterns in one of the largest Hungarian lung cancer centers

Date

16 Sep 2021

Session

ePoster Display

Presenters

Andrea Biró

Citation

Annals of Oncology (2021) 32 (suppl_5): S949-S1039. 10.1016/annonc/annonc729

Authors

A. Biró, L. Koch, Z. Matics, T. Erdélyi, V. Müller, L. Tamási

Author affiliations

  • Department Of Pulmonology, Semmelweis University, 1083 - Budapest/HU
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Abstract 1347P

Background

Real-life data on lung cancer (LC) management from Eastern Europe are scarce. We aimed to evaluate LC management data in real-life setting and to identify target areas for development in our center.

Methods

A cross-sectional analysis was performed on the data of all patients presented to the Multidisciplinary Tumor Board (MTB) of our institution from 01 June 2019 till 31 May 2020. Age, sex, smoking history, chronic obstructive pulmonary disease (COPD) as comorbidity, pathology results, the prevalence of common driver mutations, expression of programmed death ligand-1 (PD-L1), stage of the disease, performance status (PS) of the patients, applied therapeutic modalities (surgical resection, radiotherapy, systemic oncotherapy) were registered.

Results

Out of 613 patients presented to our MTB, 443 patients had positive cytology/histology for primary LC. 110 patients had no pathological verification, 60 patients were diagnosed with mesothelioma, lymphoma, metastases of other solid tumors or benign diseases. 51% of the LC patients were female; median age was 68 (range 38-91) years. 54% of LC patients were diagnosed with adenocarcinoma (AC), 28% with squamous cell carcinoma (SCC), 14% with small cell lung cancer. 51% of the lung cancer cohort had COPD, with highest prevalence in the SCC subgroup (64%). 40% of the non-small cell lung cancer (NSCLC) patients were in the early stage (IA-IIIA) of the disease at the time of the diagnosis. While 87% of our patients with early-stage AC received radical surgical treatment, only 51% of early-stage SCC patients had a curative resection. Driver mutations were found in advanced and metastatic AC cases with the following prevalences: EGFR 8%, ALK 2%, BRAF 3% (89%, 81%, 56% of cases evaluated, respectively). Immunotherapy was used as first-line treatment in 11%, in second or third line in 43% of NSCLC cases receiving systemic oncotherapy.

Conclusions

There is a high number of patients evaluated for LC but without pathological verification due to low compliance, very severe COPD, or poor PS in a large Eastern European lung cancer center. Early-stage SCC presents a challenge for surgical treatment due to the high prevalence of severe comorbidities. Immunotherapy should gain more ground for locally advanced and metastatic NSCLC.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Department of Pulmonology, Semmelweis University Budapest, Hungary.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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