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Poster Display session 1

5855 - Update of the registry of young women with cancer by the International Network of Cancer, Infertility and Pregnancy


28 Sep 2019


Poster Display session 1


Supportive Care and Symptom Management

Tumour Site


Charlotte Maggen


Annals of Oncology (2019) 30 (suppl_5): v718-v746. 10.1093/annonc/mdz265


C. Maggen1, K. Van Calsteren2, E. Cardonick3, R.G. Shmakov4, M. Gziri5, A.C. Garcia6, R. Fruscio7, C.A.R. Lok8, M. Halaska9, I.A. Boere10, P. Zola11, P. Ottevanger12, C.J.M. de Groot13, G. Scarfone14, M. Fumagalli15, R.C. Painter16, J. de Haan13, F. Amant8

Author affiliations

  • 1 Obstetrics And Gynecology, University Hospitals Leuven and Department of Oncology, KU Leuven, 3000 - Leuven/BE
  • 2 Obstetrics And Gynecology, University Hospitals Leuven and Department of Development and Regeneration, KU Leuven, Leuven/BE
  • 3 Obstetrics And Gynecology, Cooper University Hospital, Philadelphia/US
  • 4 Academician V.i.kulakov Of The Ministry Of Healthcare Of Russian Federation, National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow/RU
  • 5 Obstetrics, Cliniques Universitaires St Luc, Brussels/BE
  • 6 Oncology, Hospital Regional de Alta Especialidad de Ixtapaluca (HRAEI), Mexico City/MX
  • 7 Obstetrics And Gynecology, University of Milan-Bicocca, San Gerardo Hospital, Monza, Milan/IT
  • 8 Department Of Gynecologic Oncology, Antoni Van Leeuwenhoek Hospital – The Netherlands Cancer Institute, 1066CX - Amsterdam/NL
  • 9 Obstetrics And Gynecology, 3rd Medical Faculty Charles University and Faculty Hospital Kralovske Vinohrady, Prague/CZ
  • 10 Medical Oncology Dept, Erasmus University Medical Center, 3015 CE - Rotterdam/NL
  • 11 Department Of Surgical Sciences, University of Turin, Turin/IT
  • 12 Internal Medicine, Radboud UMC Nijmegen, Nijmegen/NL
  • 13 Obstetrics And Gynecology, Amsterdam UMC, Location VU University Medical Center, Amsterdam/NL
  • 14 Obstetrics And Gynecology, Dept Ob-Gyn University of Milan, 20121 - Milan/IT
  • 15 Neonatal Intensive Care Unit And Department Of Clinical Sciences And Community Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan/IT
  • 16 Obstetrics And Gynecology, Amsterdam University Medical Centers; Location AMC, Amsterdam/NL


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Abstract 5855


The International Network of Cancer, Infertility and Pregnancy was launched in order to register women of reproductive age with a cancer diagnosis. Over the years, the project has expanded with currently 2653 cases registered by 114 centres and an annual registration rate of 150 patients. The expected rising numbers of cancer diagnosis during pregnancy as a result of an increased age at first childbirth and the possibility of early cancer detection by the non-invasive prenatal testing calls for an ongoing evaluation of clinical practice. Moreover, women might become pregnant while exposed to adjuvant or maintenance therapies that are increasingly being used.


The INCIP database consists of a secured on-line registration tool. Oncological, obstetric and neonatal data are registered by members. Annual scientific meetings give updates on the ongoing research projects.


Most patients were registered in Belgium, the Netherlands, Italy and USA and one third of participating centres are non-European. Currently 2059 patients with a cancer diagnosis or treatment during pregnancy are registered, 395 women that received fertility preservation and 199 patients with a postnatal cancer diagnosis (Figure 1). Breast cancer, lymphoma and cervical cancer are the most frequent registered cancer types and the majority of patients (67%) received antenatal cancer treatment (Figure 2). Most women delivered a live born baby (88%), however 47% delivered preterm and 80% of preterm deliveries were medically induced. One-fifth of neonates (21%) were small for gestational age. Congenital malformations were reported in 3% of live births.


Cancer occurring in women endangers obstetrical and neonatal outcome and potentially future fertility. The INCIP registry is open for further collection of data since for such a relatively rare situation, only a large-scale project will provide better insights on maternal and foetal risks assessment, which is essential for optimal patient counselling and care.

Clinical trial identification


Editorial acknowledgement

Legal entity responsible for the study

The authors.


European Union’s Horizon 2020 research and innovation program under grant agreement No 647047.


All authors have declared no conflicts of interest.

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