Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display session 3

5753 - Trastuzumab plus docetaxel in patients with advanced HER2–positive salivary duct carcinoma: Exploratory biomarker analyses


30 Sep 2019


Poster Display session 3


Tumour Site

Head and Neck Cancers


Hideaki Takahashi


Annals of Oncology (2019) 30 (suppl_5): v449-v474. 10.1093/annonc/mdz252


H. Takahashi1, D. Kawakita2, C. Fushimi3, T. Nagao4, H. Hirai4, N. Saigusa4, T. Masubuchi3, T. Matsuki3, T. Okada3, D. Baba3, K. Miura3, T. Saotome5, Y. Tada3

Author affiliations

  • 1 Department Of Head And Neck Oncology And Surgery, International University of Health and Welfare Mita Hospital, 108-8329 - Tokyo/JP
  • 2 Department Of Otorhinolaryngology, Head And Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya/JP
  • 3 Department Of Head And Neck Oncology And Surgery, International University of Health and Welfare Mita Hospital, Tokyo/JP
  • 4 Department Of Anatomic Pathology, Tokyo Medical University School of Medicine, Tokyo/JP
  • 5 Division Of Medical Oncology, Matsudo City General Hospital, Matsudo/JP


Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract 5753


A phase II trial of trastuzumab plus docetaxel in patients with advanced HER2–positive salivary duct carcinoma (SDC) showed 70% of the overall response rate. However, biomarkers which predict survival in this population remain unknown.


A total of 91 patients with HER2–positive SDC treated with trastuzumab plus docetaxel were included. Age, sex, ECOG performance status (PS), status of visceral metastases, previous treatment, previous docetaxel exposure, previous combined androgen blockade, the best overall response to the treatment, pretreatment serum C-reactive protein (CRP) level, modified Glasgow Prognosis Score (mGPS), HER2 status (immunohistochemistry [IHC] score, HER2/CEP17 ratio, HER2 copy number, overall positivity according to ASCO/CAP Guidelines), mutational status of PIK3CA, HRAS, and TP53, IHC score of AR, Ki-67, CK5/6, p53, HER3, Akt, PI3K, FOXA1, adipophilin, mTOR and PTEN were assessed and correlated with progression-free survival (PFS) and overall survival (OS).


Treatment response (PR or CR vs. SD or PD) and PTEN IHC score (1+ – 3+ vs. 0) were related with favorable PFS (hazard ratio [HR], 0.25 and 0.39, respectively) and OS (HR, 0.29 and 0.36, respectively). CRP (≥ 0.50 mg/dL) was related with shorter PFS (HR, 2.28) and OS (HR 4.46). Presence of previous treatment and mTOR IHC (1+ – 3+ vs. 0) had significant predictive value of better PFS (HR 0.47 and 0.22, respectively) but not significantly related with OS. ECOG PS of 1-2 (vs. 0), presence of visceral metastasis, and mGPS of 1-2 (vs. 0) had significant relationship with shorter OS but not with PFS. Neither previous docetaxel exposure nor previous combined androgen blockade did not affect the survival outcome. HER2, PIK3CA, HRAS and TP53 status did not related with survival.


Although HER2 status did not correlated with survival, its downstream factors PTEN and mTOR can serve as predictive biomarkers in patients with advanced SDC treated with trastuzumab plus docetaxel. Serum CRP level may predict survival of this population.

Clinical trial identification

UMIN000009437, Released on 03/12/2012.

Editorial acknowledgement

Legal entity responsible for the study

The authors.




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.