Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display session 1

4165 - The Relation between the Symptom Burden of Hospitalized Patients with Incurable Cancer and the Quality-of-Life of Their Family Caregivers


28 Sep 2019


Poster Display session 1


End-of-Life Care

Tumour Site


Eman Tawfik


Annals of Oncology (2019) 30 (suppl_5): v661-v666. 10.1093/annonc/mdz261


E.A.E.R. Tawfik1, S.E. Abou El Kheir2, S.A. Al Hassanin1, S.F. Gohar1, D.K. Harhash1, S. Alsirafy3

Author affiliations

  • 1 Clinical Oncology Department, Faculty Of Medicine, Menoufia University,, Clinical Oncology Department, Faculty of Medicine, Menoufia University,, 561991 - Menoufia/EG
  • 2 Epidemiology, Menofia national liver institute, 561991 - Menoufia/EG
  • 3 Palliative Medicine Unit, Kasr Al-ainy Center Of Clinical Oncology And Nuclear Medicine, Kasr Al-ainy School Of Medicine, Cairo University, Cairo, Egypt, Palliative Medicine Unit, Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt, 561991 - Cairo/EG


Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract 4165


Family caregivers (FCs) play important roles in the care provided to patients with incurable cancer. These patients experience a wide range of distressing symptoms. This symptom burden may add to the burden of FCs and consequently may have a negative impact on their quality of life (QoL). This study was conducted to determine the relationship between the symptom burden in a cohort of patients with incurable cancer and the QoL of their FCs.


The study included 94 dyads of hospitalized incurable cancer patients and one of their FCs. The symptom burden among patients was assessed using the revised Edmonton Symptom Assessment System (ESAS-r) and the QoL of their FCs was measured using the Medical Outcomes Study 36-Item Short-Form (MOS SF-36) questionnaire.


Nausea was the most common symptom to associate with poorer QoL scores. There was a significant negative correlation between nausea and the following MOS SF-36 scales: physical functioning (r=-0.219, p = 0.034), role limitations due to physical health (r =-0.0228, p = 0.027), pain (r=-0.404, p < 0.001), general health (r =-0.222, p = 0.031) and health change (r=-0.317, p = 0.002). Other symptoms that correlated significantly with at least one of the MOS SF-36 scales were weakness, drowsiness, lack of appetite, shortness of breath, depression and wellbeing. The total ESAS-r score correlated significantly with poorer scores on the pain (r=-0.248, p = 0.016) and health change (r=-0.311, p = 0.002) scales of MOS SF-36. In addition; older FCs age, hours of care per day, total period of care, FCs employment and inadequate income correlated significantly with poorer scores of at least one of the MOS SF-36 scales.


The high symptom burden experienced by patients with incurable cancer may have a negative impact on the QoL of their FCs, especially the physical aspect.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Clinical Oncology Department, Menofia University.


Has not received any funding.


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.