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Poster Display session 2

4386 - SILVELUL Project: Immunohistochemical panel analyses as potential predictive and prognostic factors in Pancreatic Neuroendocrine Tumors (PanNET) Treated with CAPTEM or Everolimus


29 Sep 2019


Poster Display session 2


Tumour Site

Neuroendocrine Neoplasms;  Pancreatic Adenocarcinoma


Ana De Jesus-Acosta


Annals of Oncology (2019) 30 (suppl_5): v194-v197. 10.1093/annonc/mdz245


A. De Jesus-Acosta1, G. Crespo Herrero2, M.L. Gómez-Dorronsoro3, V. Alonso4, M.C. Riesco Martinez5, A. Custodio6, C. Lopez7, M. Benavent8, A. Carmona Bayonas9, P. Jimenez-Fonseca10, M. Llanos11, B. López De San Vicente12, V. Arrazubi Arrula13, R. Grandez14, I. González-Borja15, S. Goñi15, I. Arozarena16, M. Baretti17, A. Viudez18

Author affiliations

  • 1 Medical Oncology, Johns Hopkins Hospital, 21231 - Baltimore/US
  • 2 Medical Oncology, Hospital Universitario de Burgos (HUBU), 09006 - Burgos/ES
  • 3 Pathology, Complejo Hospitalario de Navarra - Royal Navarre Hospital, 31008 - Pamplona/ES
  • 4 Medical Oncology, Miguel Servet University Hospital, Zaragoza/ES
  • 5 Medical Oncology, University Hospital 12 De Octubre, 28041 - Madrid/ES
  • 6 Oncology, Hospital Universitario La Paz, 28046 - Madrid/ES
  • 7 Medical Oncology, Marques de Valdecilla University Hospital, Santander/ES
  • 8 Oncology, Hospital Universitario Virgen del Rocio, 41013 - Sevilla/ES
  • 9 Hematology And Medical Oncology, Hospital Universitario Morales Meseguer, 30008 - Murcia/ES
  • 10 Medical Oncology, Hospital Universitario Central de Oviedo, Oviedo/ES
  • 11 Servicio De Oncología Médica, Hospital Universitario de Canarias, Santa Cruz de Tenerife/ES
  • 12 Medical Oncology, Hospital de Basurto, 48013 - Bilbao/ES
  • 13 Medical Oncology, Complejo Hospitalario de Navarra, 31008 - Pamplona/ES
  • 14 Medical Oncology, Hospital Tudela, Tudela/ES
  • 15 Oncobionatras, Navarrabiomed, 31008 - Pamplona/ES
  • 16 Tumor Cell Signaling, Navarrabiomed, 31008 - Pamplona/ES
  • 17 Oncology, Istituto Clinico Humanitas, 20089 - Rozzano/IT
  • 18 Medical Oncology, Complejo Hospitalario de Navarra - Royal Navarre Hospital, 31008 - Pamplona/ES


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Abstract 4386


Previously our group showed the potential use of a score based on MGMT, NDRG-1 and PHLDA-3 immunohistochemistry (IHC) expression as predictor of outcome in operated PanNET. The present multicenter project is retrospectively analyzing the predictive/prognosis role of MGMT, NDRG-1 and PHLDA-3 in patients with advanced PanNET treated CAPTEM or everolimus.


IHC nuclear staining for MGMT and PHLDA-3 is being scored as 0, 1-5%, 6-50% and ≥ 51%. For NDRG-1, we are using a cytoplasmic score from 0 to 3 based on staining intensity and distribution pattern (patched or diffuse).


Until now, clinical and samples data from 96 patients (110 samples) has been collected ad are currently being analyzed. Based on our previous results, we will develop an imunohistochemistry prognostic score (IPS, score from 0 to 4) and try to correlate it with clinical variables collected in our database.


As we described previously in operated PanNET, we will try to describe the potential role of IPS as predictive/ prognostic factor in advanced PanNET. More mature results of this work will be presented during 2019 ESMO Congress.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Navarrabiomed Biomedical Research Center, Pamplona, Navarra, Spain.




All authors have declared no conflicts of interest.

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