Abstract 3690
Background
With the success of immunotherapy in various solid cancers, the expression of programmed death-ligand 1 (PD-L1) in cancer cells has been attracting attention. The aim of this study was to analyze PD-L1 expression in resected UPS and evaluate its clinical impact.
Methods
All consecutive patients who were treated with UPS in Asan Medical Center, between January 1995 and December 2016, were retrospectively reviewed. PD-L1 staining was performed using SP263 antibody on their archived tissues. PD-L1 H-score was calculated by intensity (0-3) multiplied by proportion (0-100).
Results
A total of 176 patients with localized UPS who underwent curative-intent surgical resection were included in this study. There were 104 males (59.1%) and 72 females (40.9%), and the median age of patients was 59 years at the time of diagnosis. The most frequently involved primary site was extremities (84/176, 47.7%), followed by abdomen and pelvis (46/176, 26.1%), thorax (29/176, 16.5%), and head and neck (17/176, 9.7%). The PD-L1 analysis was available on slides from 114 (64.8%) patients and PD-L1 expression was observed in 83 (72.8%) cases. Intensity of staining varied between weak (44/83, 53.0%), intermediate (29/83, 34.9%), strong (10/83, 12.0%). Distribution of PD-L1 expression using different cut-off values were as follows: ≥1%: 83/114 (72.8%); ≥5%: 79/114 (69.3%); ≥10%: 52/114 (45.6%); ≥50%: 20/114 (17.5%). The 5-year disease free survival (DFS) rate seemed to be better in patients with PD-L1 positive than in patients with PD-L1 negative (56.5% vs 41.9%), but no statistical significant was observed (p = 0.183). There was a trend for better 5-year DFS rate with higher proportion of PD-L1 or higher PD-L1 H-score (proportion: 0% vs 1-49% vs ≥ 50, 41.9% vs 52.9% vs 70.1%, p = 0.098; H-score: 0 vs 1-100 vs ≥ 101, 41.9% vs 53.1% vs 75.7%, p = 0.087) without statistical singnificance.
Conclusions
In this study, PD-L1 protein expression was seen in substantial cases of resected UPS and it appeared to be a positive prognostic biomarker for longer DFS, although not statistically demonstrated. Further studies are needed comprehensively understand the impact of immune repertoire in UPS.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
4369 - Biomarker testing of lung cancer in Spain
Presenter: Delvys Rodriguez Abreu
Session: Poster Display session 1
Resources:
Abstract
603 - Mendelian Randomization Study of Alzheimer's Disease and Lung Cancer
Presenter: Huaqiang Zhou
Session: Poster Display session 1
Resources:
Abstract
4462 - Spanish registry of thoracic tumors (TTR): Interim analyses of comorbidities, risk associations, personal and family history of cancer
Presenter: Rafael Lopez Castro
Session: Poster Display session 1
Resources:
Abstract
3957 - Pleural effusion TGF-beta is highly diagnostic and prognostic in malignant pleural mesothelioma
Presenter: Paul Stockhammer
Session: Poster Display session 1
Resources:
Abstract
3583 - Immune microenvironment modulation by p14/ARF in Malignant Pleural Mesothelioma
Presenter: Giulia Pasello
Session: Poster Display session 1
Resources:
Abstract
4255 - Tumor Treating Fields plus chemotherapy for first-line malignant pleural mesothelioma (MPM): radiological responses in the STELLAR trial
Presenter: Federica Grosso
Session: Poster Display session 1
Resources:
Abstract
1803 - Effects of Tumor Treating Fields (TTFields; 150 kHz) and Cisplatin or Pemetrexed Combination Therapy on Mesothelioma cells In Vitro and In Vivo
Presenter: Mijal Munster
Session: Poster Display session 1
Resources:
Abstract
2660 - Real world use of systemic therapy in elderly patients with malignant pleural mesothelioma (MPM)
Presenter: Susana Cedres
Session: Poster Display session 1
Resources:
Abstract
3150 - Pemetrexed/Cisplatin versus Gemcitabine/Cisplatin as first-line treatment for Egyptian patients with malignant pleural mesothelioma
Presenter: Mohamed Alorabi
Session: Poster Display session 1
Resources:
Abstract
4319 - Accuracy of pathologic evaluation for thymic epithelial tumors in an Italian reference Centre
Presenter: Giulia Galli
Session: Poster Display session 1
Resources:
Abstract