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Poster Display session 2

5876 - Palbociclib-Fulvestrant (PALBO-FUL) and Everolimus -Exemestane (EVE-EXE) for Second line Hormonal Treatment (HT) of Metastatic Breast Cancer (MBC) with Lobular Histology: a Propensity Score Matched Analysis of a Multicenter ‘Real-World’ Patients (pts) Series.

Date

29 Sep 2019

Session

Poster Display session 2

Topics

Tumour Site

Breast Cancer

Presenters

Armando Orlandi

Citation

Annals of Oncology (2019) 30 (suppl_5): v104-v142. 10.1093/annonc/mdz242

Authors

A. Orlandi1, E. Iattoni1, L. Pizzuti2, M.A. Fabbri3, A. Botticelli4, C. Di Dio1, A. Palazzo1, G. Garufi1, G. Indellicati1, D. Alesini3, L. Carbognin5, I. Paris5, A. vaccaro6, L. Moscetti7, A. Cassano1, P. Vici8, D. Giannarelli9, P. Marchetti10, E. Bria1, G. Tortora1

Author affiliations

  • 1 Cancer Center Uoc Di Oncologia Medica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 - Rome/IT
  • 2 Division Of Medical Oncology B, Istituto Nazionale Tumori Regina Elena, 00144 - Rome/IT
  • 3 Medical Oncology, Central Hospital of Belcolle, 01100 - Viterbo/IT
  • 4 Clinical And Molecular Medicine Dept., Sapienza University of Rome, 00189 - Rome/IT
  • 5 Division Of Gynecologic Oncology, Department Of Woman And Child Health, Fondazione Policlinico Universitario A. Gemelli, I.R.C.C.S., Università Cattolica del Sacro Cuore, 00168 - Roma/IT
  • 6 Oncology Department, Frosinone, 00000123 - frosinone/IT
  • 7 Oncology Department, Azienda Ospedaliero - Universitaria Policlinico di Modena, 41125 - Modena/IT
  • 8 Division Of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 - Roma/IT
  • 9 Biostatistical Unit, Regina Elena National Cancer Institute, 00144 - Rome/IT
  • 10 Medical Oncology, Sapienza, University of Rome, Medical Oncology Unit, 00189 - Rome/IT

Resources

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Abstract 5876

Background

Recently, CDK4/6i proved to improve the efficacy of HT of pts affected by luminal MBC. However, the best sequence of HT is still unclear and it is still uncertain if pts with lobular histology derive the same benefit of ductal when receiving second line CDK4/6i. Particularly in lobular MBC, the dysregulation of the AKTpathway with the overexpression of cyclin E potentially represents an important mechanism of acquired resistance to HT, finally providing an intrinsic resistance to subsequent CDK4/6i. Thus, a multicentric retrospective study was conducted to determine the efficacy of PALBO-FUL versus EVE-EXE as second line HT of MBC with Lobular histology.

Methods

Pts affected by Lobular MBC receiving PALBO-FUL or EVE-EXE for second line HT from 2013 to 2018 in 6 Italian centers were considered eligible. The primary endpoint was progression free survival (PFS). A propensity score (PS) adjustment for baseline characteristics was further accomplished for survival analysis.

Results

Seventy-four of 376 screened pts were diagnosed for Lobular MBC; 48pts received PALBO-FUL, whereas 26 were treated with EVE-EXE, without imbalance in clinical characteristics. PFS resulted to be significantly longer for pts receiving EVE-EXE in comparison with PALBO-FUL (6.1 vs. 4.5 months, univariate HR 0.58, 95% CI 0.35-0.96; p = 0.025). Previous chemotherapy exposure resulted to be significantly associated with PFS at the multivariate analysis (HR 0.41, 95% CI 0.24-0.72, p = 0.002). At the PS analysis, adjusted for previous chemotherapy exposure and synchronous/metachronous metastatic status, PFS was confirmed to be significantly longer for pts receiving EVE-EXE in comparison with PALBO-FUL (6.0 vs. 4.6 months, p = 0.04).

Conclusions

This retrospective real-world analysis generates the hypothesis of a potential benefit of EVE-EXE in comparison with PALBO-FUL for second line HT of MBC with Lobular histology, and it allows to speculate on the best therapeutic sequence. Nevertheless, the small pts’ sample calls for a larger and adequately sized prospective validation.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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