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Poster Display session 2

1837 - Oncological impact of re-excision for positive margin status after breast conserving surgery in invasive breast cancer


29 Sep 2019


Poster Display session 2


Tumour Site

Breast Cancer


Kenjiro Jimbo


Annals of Oncology (2019) 30 (suppl_5): v55-v98. 10.1093/annonc/mdz240


K. Jimbo1, C. Watase2, U. Nakadaira2, T. Murata2, S. Shiino2, S. Takayama2, A. Suto2

Author affiliations

  • 1 Breast Suegery Division, National Cancer Center Hospital, 104-0045 - Tokyo/JP
  • 2 Breast Surgery Division, National Cancer Center, 1040045 - Tokyo/JP


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Abstract 1837


Positive margin of breast-conserving surgery (BCS) is well known to be a risk factor for ipsilateral breast tumor recurrence (IBTR). SSO/ASTRO guidelines defined ink on invasive cancer or DCIS as positive margin and recommend considering doing re-excision of the site of positive margin. However, whether re-excision can reduce IBTR has not been fully investigated yet. The aim of this study was to retrospectively assess the oncological impact of re-excision for positive margin status after BCS in invasive breast cancer.


The subjects were 196 invasive breast cancer patients who underwent BCS, and who were found to have positive margin. Of the 196 patients, 55 underwent re-excision after initial BCS (group A), and 139 did not (group B). We analyzed IBTR free survival in each group and evaluated the predictors for IBTR and overall survival (OS) using Cox proportional hazards modeling.


Of the 196 patients, 188 (96%) underwent adjuvant radiotherapy and 24 of 55 re-excision (43%) identified residual disease. There was no significant difference in 10-year IBTR free survival between group A and group B (94.4% versus 93.8%; P = 0.58). In a multivariate analysis, re-excision was not associated with IBTR and OS, while younger age, lack of adjuvant radiotherapy, and invasive component of margin status were independent predictors of IBTR.


In our retrospective study, re-excision for positive margin after initial BCS in invasive breast cancer does not contribute to prevent IBTR and may not translate into improved OS. Further treatment should be considered when patient was younger and margin status was invasive component.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Kenjiro Jimbo.


Has not received any funding.


All authors have declared no conflicts of interest.

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