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Poster Display session 2

3875 - Correlation of radiotherapy with the prognosis of elderly patients with hormone receptor-positive breast cancer according to immunohistochemical subtyping


29 Sep 2019


Poster Display session 2


Tumour Site

Breast Cancer


Jin Zhang


Annals of Oncology (2019) 30 (suppl_5): v104-v142. 10.1093/annonc/mdz242


J. Zhang

Author affiliations

  • Breast Cancer Department, Tianjin Cancer Hospital, 300060 - Tianjin/CN


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Abstract 3875


The present study examined the effect of radiotherapy on recurrence and survival in elderly patients with hormone-receptor-positive early breast cancer.


A retrospective analysis of 327 patients aged ≥65 years with stage I-II, hormone receptor positive breast cancer who underwent breast conserving surgery and received endocrine therapy (ET) or radiotherapy plus endocrine therapy (ET+RT) was performed. Both groups were divided into luminal A type and luminal B type subgroups. Evaluation criteria were 5-year disease free survival (DFS), local relapse rate (LRR), overall survival (OS), and distant metastasis rate (DMR).


There were significant differences in 5-year DFS (HR 1.59, 95% CI 1.15–2.19, P = 0.005) and LRR (HR 3.33, 95% CI 1.51–7.34, P = 0.003), whereas there were no significant differences in OS and DMR between the two groups. In luminal A type, there was no significant difference in 5-year DFS, LRR, OS, and DMR between the ET group and the ET+RT group. In luminal B type, there were statistically significant differences in 5-year DFS (HR 2.188, 95% CI 1.37–3.49, P = 0.001), LRR (HR 5.447, 95% CI 1.65–17.98, P = 0.005), and OS (HR 1.752, 95% CI 1.01–3.054, P = 0.048) between the two groups. In the ET group, there were significant differences between luminal A type and luminal B type in 5-year DFS (HR 1.841, 95% CI 1.23–2.75, P = 0.003) and OS (HR 1.763, 95% CI 1.07–2.91, P = 0.026).


After breast conserving surgery, radiotherapy can reduce the LRR and improve the DFS and OS of luminal B type elderly patients, whereas luminal A type elderly patients do not benefit from radiotherapy. Without radiotherapy, luminal A type patients have better DFS and OS than luminal B type patients.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The author.


National Natural Science Foundation of China (81672623).


The author has declared no conflicts of interest.

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