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Poster Display session 1

2299 - Comparison of three different chemotherapy regimens for concomitant chemoradiotherapy in locally advanced non small cell lung cancer

Date

28 Sep 2019

Session

Poster Display session 1

Topics

Tumour Site

Non-Small Cell Lung Cancer

Presenters

Abdurrahman Işıkdoğan

Citation

Annals of Oncology (2019) 30 (suppl_5): v591-v601. 10.1093/annonc/mdz259

Authors

A. Işıkdoğan1, N. Akdeniz2, M. Küçüköner1, M.A. Kaplan1, Z. Urakçı1, O. Karhan1, Y. Sezgin1, E. Bilen1, S. Ebinç1, F. Teke3, Ş. Laçin4, O. Alan5, O. Ercelep6, F. Yumuk7

Author affiliations

  • 1 Department Of Medical Oncology, Dicle University Medical Faculty, 38000 - Diyarbakır/TR
  • 2 Department Of Medical Oncology, Dicle University Medical Faculty, 21080 - Diyarbakır/TR
  • 3 Department Of Radiation Oncology, Dicle University Medical Faculty, 38000 - Diyarbakır/TR
  • 4 Department Of Medical Oncology, Gazi Yasargil Education and Training Hospital, 21010 - Diyarbakır/TR
  • 5 Department Of Medical Oncology, Marmara University Medical Faculty, 34600 - Istanbul/TR
  • 6 Department Of Medical Oncology, Marmara University Medical Faculty, 34890 - Istanbul/TR
  • 7 Department Of Medical Oncology, Marmara University Medical Faculty, 48000 - Istanbul/TR

Resources

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Abstract 2299

Background

The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context.

Methods

A total of 225 patients with locally advanced, unresectable stage III NSCLC included. Patients who treated with weekly docetaxel-platin (DP), paclitaxel-platin (PP) and standard dose etoposide-platin (EP) chemotherapy regimens were selected and divided to groups for the comparison of toxicity, response rate, progression free survival (PFS) and overall survival (OS) rates.

Results

There was statistically significant difference between overall response rate of each treatment groups (DP: 96,1%, PP: 94% and EP:76.7%, p < 0.001). The median PFS rate of patients who treated with DP, PP and EP was 16, 15 and 13.3 months, respectively (p = 0.435). The median OS of patients treated with DP, PP and EP was 19.2, 29.7 and 28.3 months, respectively (p = 0.092). The rates of adverse events such as nausea, vomiting, neuropathy and anaphylaxis was similar. Grade 1-2 mucositis or esophagitis, anemia, pneumonitis were significantly higher in PP group than other groups. However, hematologic toxicities were higher in the EP group than other groups.Table:

1464P

Patients characteristics
DP (N = 102) N(%)PP (N = 50) N(%)EP (N = 73) N(%)P
Median age6164580.038
Gender Male93(91.2)48(96)64(87.7)0.28
Histopathology Squamous cell53(52)31(62)43(58.9)<0.001
Stage IIIB-IIIC65(63.7)31(62)41(56.2)0.59

Conclusions

When the weekly chemotherapy regimens were compared with the standard dose, our study demonstrated similar survival rates but better treatment response rates. Adverse events and toxicity rates were different and depending on the type of chemotherapy regimen used.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Abdurrahman Işıkdogan.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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