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Poster Display session 1

2168 - Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy


28 Sep 2019


Poster Display session 1


Supportive Care and Symptom Management

Tumour Site


Tineke Vandenbroucke


Annals of Oncology (2019) 30 (suppl_5): v718-v746. 10.1093/annonc/mdz265


T. Vandenbroucke1, M. Verheecke1, M. van Gerwen2, K. Van Calsteren3, M. Halaska4, M. Fumagalli5, R. Fruscio6, M. Veening7, L. Lagae8, P. Ottevanger9, J. Voigt10, J. de Haan11, M. Gziri12, A. Gandhi13, C. Maggen1, L. Mertens14, G. Naulaers15, L. Claes13, F. Amant16

Author affiliations

  • 1 Obstetrics And Gynecology, University Hospitals Leuven and Department of Oncology, KU Leuven, 3000 - Leuven/BE
  • 2 Center For Gynecologic Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam/NL
  • 3 Obstetrics And Gynecology, University Hospitals Leuven and Department of Development and Regeneration, KU Leuven, Leuven/BE
  • 4 Obstetrics And Gynecology, 3rd Medical Faculty Charles University and Faculty Hospital Kralovske Vinohrady, Prague/CZ
  • 5 Neonatal Intensive Care Unit And Department Of Clinical Sciences And Community Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan/IT
  • 6 Obstetrics And Gynecology, University of Milan-Bicocca, San Gerardo Hospital, Monza, Milan/IT
  • 7 Pediatric Oncology, Princess Máxima Center for pediatric oncology, Utrecht/NL
  • 8 Pediatrics, University Hospitals Leuven, Leuven/BE
  • 9 Internal Medicine, Radboud UMC Nijmegen, Nijmegen/NL
  • 10 Cardiology, University Hospitals Leuven, Leuven/BE
  • 11 Obstetrics And Gynecology, Amsterdam UMC, Location VU University Medical Center, Amsterdam/NL
  • 12 Obstetrics, Cliniques Universitaires St Luc, Brussels/BE
  • 13 Faculty Of Psychology And Educational Sciences, KU Leuven, Leuven/BE
  • 14 Cardiology, The Hospital for Sick Children, Unversity of Toronto, Toronto/CA
  • 15 Neonatology, University Hospitals Leuven, Leuven/BE
  • 16 Department Of Gynecologic Oncology, Antoni Van Leeuwenhoek Hospital – The Netherlands Cancer Institute, 1066CX - Amsterdam/NL


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Abstract 2168


Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce.


In a multicentre cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy (study group) were compared to the outcome of children born after an uncomplicated pregnancy (control group) (ClinicalTrials.gov, NCT00330447). Neurodevelopment was assessed by clinical evaluation and neuropsychological testing (including intelligence, attention and memory tests) and by general health and behaviour questionnaires. Cardiac evaluation included electro- and echocardiography.


In total, 132 study children and 132 controls (mean age 6.2 years) were included. In the study group, 97 children (73.5%) were prenatally exposed to chemotherapy (alone or in combination with other treatments), 14 (10.6%) to radiotherapy (alone or in combination), 1 (0.8%) to trastuzumab, 12 (9.1%) to surgery alone and 16 (12.1%) to no treatment. Although within normal ranges, the mean Verbal IQ score was significantly lower in the study versus control group (98.9 vs 103.0, p = 0.001, q < 0.001). Also, children in the study group had a significantly lower score for visuospatial long-term memory compared to the control group (3.9 vs 4.5, p = 0.005, q = 0.043). No significant differences were found in Full Scale IQ, Performance IQ, Processing Speed, memory span, verbal and visuospatial short-term memory, attention and behaviour problems or in cardiac dimensions and left ventricular function.


Children prenatally exposed to maternal cancer and its treatment may be at risk for lower Verbal IQ and visuospatial long-term memory scores, but other cognitive functions and cardiac outcomes were normal at the age of 6 years.

Clinical trial identification


Editorial acknowledgement

Legal entity responsible for the study

University Hospitals Leuven, Belgium.


European Union’s Horizon 2020 research and innovation programme under grant agreement No. 647047, Research Foundation-Flanders (F.W.O)., Stichting tegen Kanker, Belgian Cancer Plan, Koningin Wilhemina Fonds (K.W.F.), Kom Op Tegen Kanker, Stichting Mitialto and Charles University grant Progres Q-34.


All authors have declared no conflicts of interest.

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