Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display session 1

4740 - Characteristics, incidence, and survival of primary cerebral lymphoma: A population based study


28 Sep 2019


Poster Display session 1


Tumour Site

Lymphomas;  Central Nervous System Malignancies


Sherief Ghozy


Annals of Oncology (2019) 30 (suppl_5): v143-v158. 10.1093/annonc/mdz243


S. Ghozy1, M. Dibas2, A.M. Afifi3, M. A. Hashim4, A.S. Abbas5, M. M. Abdel-Daim6

Author affiliations

  • 1 Neurosurgery Department, El Sheikh Zayed Specialized Hospital, 2170 - Giza/EG
  • 2 College Of Medicine, Sulaiman Al-Rajhi Colleges, 1122 - Qassim/SA
  • 3 Faculty Of Medicine, Ain Shams University, 11361 - Cairo/EG
  • 4 Department Of Cardiovascular Diseases, University of Kentucky, Lexington/US
  • 5 Faculty Of Medicine, Minia University, 2100 - Minia/EG
  • 6 Pharmacology Department, Faculty Of Veterinary Medicine, Suez Canal University, Ismailia/EG


Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 4740


Primary cerebral lymphoma (PCL) is a rare malignancy representing less than 1.5% of brain tumors. Given the lack of studies in the literature that describe PCL, we used data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate PCL’s prognostic factors, incidence and survival rates.


We conducted a retrospective population-based cohort study using SEER database from 1983-2014. Patients with primary lymphoma as their only primary malignancy analyzed. Patients who were diagnosed by autopsy, had no active follow up in the registry and with unknown Ann Arbor Staging, or radiology status were excluded. We also calculated the frequencies and the average annual age-adjusted rate (AAR) of PCL patients between 2000 and 2015. Uni- and multivariable accelerated failure time regression were used to identify possible prognostic factors affecting the patient’s survival.


We identified 1,196 PCL cases, with an average age of diagnosis 56.71 ± 17.28 years and 59.9% were males. Diffuse B-cell lymphoma was the most prevalent sub-type (61.3%). AAR was 0.14 per 100,000. These rates were higher in males, Asian or Pacific Islander and increasing with age. PCL-specific 1-year, 2-year, and 5-year survival rates were 89.6%, 84.4%, and 67%, respectively. Increased age (HR: 1.02, 95%CI=1.01–1.03, P < 0.001) and recent diagnosis after 2002 (HR: 2.42, CI = 1.46–3.42, P < 0.001) were significantly associated with shorter survival, while having a PCL in the temporal lobe (HR: 0.62, 95%CI=0.40–0.98, P = 0.040), or parietal lobe (HR: 0.63, 95%CI=0.42–0.94, P = 0.024) as compared to the other sites, and receiving radiation (HR: 0.37, 95% CI = 0.15–0.92, P = 0.033) or chemotherapy (HR: 0.64, 95%CI=0.50–0.83, P = 0.001) were associated with improved survival.


This is the first report to shed light on PCL’s incidence, survival rate, and prognostic factors. As a result, it will provide physicians and researchers with insights about this rare malignancy.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Sherief Ghozy.


Has not received any funding.


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.