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Poster Display session 3

5271 - A Pilot Study to Implement an Artificial Intelligence (AI) System for Gastrointestinal Cancer Clinical Trial Matching


30 Sep 2019


Poster Display session 3


Translational Research

Tumour Site


Zhaohui Jin


Annals of Oncology (2019) 30 (suppl_5): v574-v584. 10.1093/annonc/mdz257


Z. Jin1, T. Haddad1, J. Hubbard1, M.L. Hartgers1, K. Leventakos1, K. Cornwell2, K. King2, B.A. Franke2, K. Pomerleau3, V. Bibeau4, S. Coverdill5, M. Rammage5, J. Helgeson3, A. Mahipal1

Author affiliations

  • 1 Medical Oncology, Mayo Clinic, 55905 - Rochester/US
  • 2 Medical Oncology Clinical Research, Mayo Clinic, 55905 - Rochester/US
  • 3 Research Administrative Services, Mayo Clinic, 55905 - Rochester/US
  • 4 Management Engineering & Internal Consulting, Mayo Clinic, 32224 - Jacksonville/US
  • 5 Ibm Watson Health, IBM, 02142 - Cambridge/US


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Abstract 5271


Clinical trials improve our knowledge of diseases and treatments while providing patients access to investigational agents. However, approximately 3% of newly diagnosed cancer patients are enrolled in clinical trials in the United States. Identifying an appropriate trial for a patient is time-consuming and cumbersome in the busy clinical practice. The Watson for Clinical Trial Matching (CTM) cognitive system uses AI to derive patient and cancer-related attributes from structured and unstructured text found in the electronic health record. These attributes are matched to complex eligibility criteria in clinical trial protocols.


In April 2019, a pilot study was launched to test the feasibility of implementing CTM in Gastrointestinal (GI) oncology at Mayo Clinic in Rochester, MN. Two clinical research coordinators (CRCs) screened patients for potential clinical trials prior to their clinic visits using both CTM and the traditional manual screening method. To avoid bias, each CRC screened a separate set of patients by both methods alternating which methodology was used first. The clinical trial match results were blinded to both CRCs. For each method, time to complete the screen and number of potential clinical trial matches were recorded.


A total of 35 GI cancer patients with new diagnosis, recent resection or restaging scans were analyzed. Patients were evaluated against 50 GI-specific drug therapy and multi-disease phase I clinical trials. Clinical trial matching using CTM took an average of 10.1 minutes (Range: 4 to 20 min) per patient compared to an average of 30.5 minutes (Range: 5 to 75 min) per patient (p < 0.0001) using the manual method. CTM identified an average of 7.66 clinical trials (Range: 0-16) while the manual screening method identified an average of 1.97 clinical trials (Range: 0 to 6) per patient (p < 0.0001).


Implementation of Watson for CTM system with a CRC team may enable high volume patient screening for a large number of clinical trials in an efficient manner and promote awareness of clinical trial opportunities within the GI oncology practice. Further analysis to evaluate CTM accuracy and impact on enrollment is warranted and currently underway.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.


Mayo Clinic.


T. Haddad: Advisory / Consultancy: TerSera Therapeautics; Research grant / Funding (self): Takeda. S. Coverdill: Full / Part-time employment: IBM Watson Health; Shareholder / Stockholder / Stock options: IBM. M. Rammage: Full / Part-time employment: IBM Watson Health; Licensing / Royalties: IBM. All other authors have declared no conflicts of interest.

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