Abstract 173P
Background
Gastric cancer (GC) is a significant global health burden, ranking as the third leading cause of cancer deaths worldwide and the fifth most frequently diagnosed cancer. GC prognosis depends on many different factors and these and mainly the stage. Although literature concerning the association between GC location and prognosis is limited, certain studies suggest that tumor localization may influence GC prognosis, particularly in the early stages. However, further investigation is warranted. GC is categorized based on tumor location into two main types: proximal GC (PG) and distal GC (DG). In our study, we divided GC location into three main groups proximal, body, and distal.
Methods
This is a retrospective study of patients with gastric cancers who have been discussed at the Upper GI MDT between January 2018 and December 2020 at National Center for Cancer Care and Research in Qatar.
Results
We conducted a retrospective analysis of electronic records from 206 patients treated for gastric adenocarcinoma at NCCCR. Utilizing Excel, we found no statistically significant discrepancy in overall survival concerning anatomical location in stage 4 gastric cancer. In locally advanced stages, tumors located distally exhibit prolonged overall survival compared to those situated proximally or in the body, with median overall survival durations of 28, 20, and 12 months, respectively. Notably, the median overall survival among distal gastric cancer cases exceeds that of proximal cases by 14 months, with a statistically significant p-value of 0.04. Evidence has shown that surgery improves survival rates in early-stage gastric cancer. In our study, we compared the overall survival between patients who underwent surgical removal and those who did not. Surprisingly, we found no statistically significant difference in overall survival based on anatomical distribution, suggesting that factors other than surgical intervention may account for the observed variability in survival rates.
Conclusions
Tumor location appears to be a relevant factor in gastric cancer prognosis, alongside stage. Further studies are warranted to look for underlying mechanisms and implications for treatment.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.