Abstract 277P
Background
To characterize ductal adenocarcinoma of the prostate by comparing VASH1 expression levels in ductal and acinar adenocarcinoma of the prostate.
Methods
125 patients who underwent radical prostatectomy or transrectal resection over the past 5 years, 14 patients diagnosed with ductal adenocarcinoma and 20 patients with acinar adenocarcinoma with Gleason scores of 4+4 were included in the study. VASH1 density was taken as the number of activated endothelial cells (number of vessels per mm2), microvessel density (MVD) was determined through CD34 expression, all results were obtained by immunohistochemistry. The main method for evaluating the results was to determine the presence of a relationship between MVD and VASH1 density in ductal and acinar adenocarcinoma, the secondary method for evaluating the results was the oncological outcomes of these forms of cancer.
Results
9 patients (64.3%) with ductal adenocarcinoma were diagnosed with advanced clinical stage and 5 patients (35.7%) died of cancer during a median follow-up period of 56.0 months. VASH1 density (mean ± SD) in ductal and acinar adenocarcinoma was 45.1 ± 18.5 vs. 16.1 ± 21.0 (p < 0.001), respectively, while MVD (mean ± SD) in ductal and acinar adenocarcinoma was 65.3 ± 21.9 versus 80.8 ± 60.7. (p = 0.666), respectively. The five-year survival rate for high and low VASH1 expression was 70.0% and 100.0% (p = 0.006), respectively. High expression of VASH1 and diagnosis of ductal adenocarcinoma were important predictors of survival.
Conclusions
Ductal adenocarcinoma has more aggressive growth and higher expression of VASH1 than acinar adenocarcinoma, with MVD rates being equivalent in both forms of prostate cancer. The obtained results suggest that the level of VASH1 expression may be a new biomarker for the aggressive course of ductal adenocarcinoma.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Republican Cancer Research Center of Uzbekistan.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.
Resources from the same session
415P - Initial experience in a real-world Asian cohort with a circulating tumor DNA (ctDNA) mutation-based multi-cancer early detection (MCED) assay
Presenter: Steven Tucker
Session: Poster Display
Resources:
Abstract
416P - Three-dimensional bioprinting model of ovarian cancer for identification of patient-specific therapy response
Presenter: Jiangang Zhang
Session: Poster Display
Resources:
Abstract
417P - Early experience in using plasma-only multi-omic minimal residual disease testing in early-stage colorectal cancer patients from Asia and the Middle East
Presenter: Shaheenah Dawood
Session: Poster Display
Resources:
Abstract
418P - Decoding the intricate cellular makeup of immune-related adverse events using single-cell and spatial analysis
Presenter: Dmitrii Shek
Session: Poster Display
Resources:
Abstract
420P - Combinatory genomic and transcriptomic sequencing of Chinese KRAS mutant non-small cell lung cancer revealed molecular and inflammatory heterogeneity in tumor microenvironment
Presenter: Xuchao Zhang
Session: Poster Display
Resources:
Abstract
421P - Comprehensive genomic profiling (CGP) unravels somatic BRCA (sBRCA) and homologous recombinant repair (HRR) gene alterations across multi-cancer spectrum
Presenter: Ramya Kodandapani
Session: Poster Display
Resources:
Abstract
422P - CD8Teff distinguished tumor immunotyping heterogeneity and enables precision immunotherapy
Presenter: luhui Mao
Session: Poster Display
Resources:
Abstract
423P - Insights into clinically actionable biomarkers in an Indian cancer cohort of 1000 patients using comprehensive genomic profiling (CGP)
Presenter: Mithua Ghosh
Session: Poster Display
Resources:
Abstract
424P - MD Anderson Cancer Center global precision oncology decision support (Glo-PODS) clinical trial genomic support: Pilot program at the Prince of Wales Hospital (Chinese University of Hong Kong - CUHK)
Presenter: Brigette Ma
Session: Poster Display
Resources:
Abstract
425P - Engineered <italic>Lactococcus lactis</italic> as a personalized cancer vaccine platform induces antitumour immunity via membrane-inserted peptide for neoantigens
Presenter: Meng Zhu
Session: Poster Display
Resources:
Abstract