Abstract 18P
Background
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2 (HER2-) negative early breast cancers (eBCs) represent a significant health concern in the Indian population. Among premenopausal women with HR+ eBC, adjuvant ovarian function suppression (OFS) is considered as an integral component of treatment; however, its optimal utilization remains a subject of ongoing debate.
Methods
In response to identified gaps in clinical practice, a comprehensive questionnaire consisting of 28 statements was developed. These statements were reviewed and validated by a scientific committee, ensuring their accuracy and relevance to the study's objectives. A panel of 46 Indian experts and 1 global expert in the field of eBC were asked to rate their level of agreement/disagreement with each statement. Consensus was defined as achieving a ≥ 80% majority agreement among participants.
Results
Following two rounds of the modified Delphi technique, consensus was achieved on 19 out of 28 statements addressing critical aspects of premenopausal HR+ HER2- eBC management. The expert panel strongly recommends a comprehensive risk stratification approach for premenopausal HR+ HER2- eBC patients. Notably, Patients ≤40 years old are deemed high-risk candidates, recognizing age as an independent risk factor. For patients ≥40 years, a composite assessment incorporating clinicopathological factors (tumor grade, nodal involvement, and Ki67 score) is advised for risk assessment. For high-risk patients, OFS coupled with an Aromatase Inhibitor emerged as a recommended therapeutic strategy. The panel recommends a potential duration of up to 5 years for OFS, provided tolerability is maintained. In patients below 40 years of age, simultaneous initiation of OFS with chemotherapy is advised, while in those aged over 40 years, sequential initiation is deemed acceptable. Among the available LHRH agonists, Triptorelin stands out as the preferred choice, although the panel acknowledges similar efficacy across all options.
Conclusions
The outcomes of this consensus offer valuable guidance, enabling individualized and evidence-based approaches for OFS in Indian patients with HR+ HER2- eBC.
Clinical trial identification
Editorial acknowledgement
BioQuest Solutions Pvt Ltd.
Legal entity responsible for the study
Dr. Reddy's Laboratories.
Funding
Dr. Reddy's Laboratories.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
472P - Risk of recurrence and optimal adjuvant treatment in invasive lung adenocarcinomas manifesting as radiological part-solid nodules
Presenter: Yang Wo
Session: Poster Display
Resources:
Abstract
473P - Treatment (tx) patterns in resectable stage IA–IIIA non-small cell lung cancer (NSCLC) in China: Subgroup analysis of a global real-world (rw) study
Presenter: Chih-Chi Yang
Session: Poster Display
Resources:
Abstract
474P - The efficacy of image guided coil localisation for surgical resection of undiagnosed solitary lung nodule
Presenter: Jun Rey Leong
Session: Poster Display
Resources:
Abstract
475P - 5-year overall survival and disease free survival outcome between lobectomy and segmentectomy for early stage lung cancer in a mixed Asian population
Presenter: Jianye Chen
Session: Poster Display
Resources:
Abstract
478P - Peri-operative risks in curative lung resection of early stage primary lung cancer patients above 70 years old in a mixed Asian population
Presenter: Ian Goh
Session: Poster Display
Resources:
Abstract
480P - Aumolertinib as adjuvant therapy for resectable stage I-III EGFR-mutant NSCLC: Also effective in EGFR co-mutation
Presenter: Lin Wu
Session: Poster Display
Resources:
Abstract
481P - Comparative analysis of three NGS platforms assessing tumor mutational burden and mutational landscape in resectable non-small cell lung cancer
Presenter: Jii Bum Lee
Session: Poster Display
Resources:
Abstract
482P - Prevalence of EGFR mutations (EGFRm) and its subtypes in patients (pts) with resected stage I-III NSCLC: Results from EARLY-EGFR Singapore cohort
Presenter: Puey Ling Chia
Session: Poster Display
Resources:
Abstract
483P - Genetic profiles and evolutionary trajectory of early stage lung adenocarcinoma (AAH, AIS, MIA and IAC) revealed by multiplex sequecing
Presenter: lixuan lin
Session: Poster Display
Resources:
Abstract
484P - Treatment (tx) patterns and outcomes in resectable early-stage EGFR-mutated (EGFRm) NSCLC in South Korea: Subgroup analysis of a global real-world (rw) study
Presenter: Myung-Ju Ahn
Session: Poster Display
Resources:
Abstract