Abstract 572P
Background
Lung cancer was the leading cause of mortality in 2022, with 38.4% of patients having non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. EGFR tyrosine kinase inhibitors (TKIs) are the first-line treatment for EGFR-mutated NSCLC. A limited number of patients achieved five-year survival. This retrospective study aimed to provide real-world evidence and explore the factors affecting the five-year survival of patients with EGFR-mutated NSCLC.
Methods
This study included patients with EGFR-mutated NSCLC treated in Chang Gung Memorial Hospitals between 2011 and 2016, ensuring at least five years of follow-up or mortality. Odds ratios (ORs) were calculated using univariate and multivariate analyses. A scoring system based on a logistic regression model was designed to evaluate factor weightings on patients’ five-year survival. Their overall survival probability was estimated using the Kaplan-Meier model. The model’s accuracy was assessed using the area under the receiver operating characteristic curve (AUC).
Results
Of 1,873 enrolled patients, 185 were lost to follow-up within five years, leaving 1,787 for analysis. Of patients achieving five-year survival, more were female, age 65 years, had performance scores of 0∼1, no metastases, and adequate objective responses and disease control. A scoring system was developed by assigning points to each prognostic factor associated with increased risk of not achieving five-year survival: age > 65 years (1 point); performance score of 2∼4 (2 points); stage IV disease (1 point); liver (2 points), bone (1 point), or pleura (1 point) metastasis; and poor disease control (2 points). In the Kaplan-Meier model, the estimated five-year survival rate was 39.4%, 13.0%, 7.2%, and 2.2% for the low-risk (0∼1 point), intermediate-risk (2 points), high-risk (3 points), and very-high-risk (4∼10 points) groups, respectively. The prediction model’s AUC was 0.787 (95% CI: 0.752∼0.821), indicating fair accuracy.
Conclusions
We proposed a scoring system based on real-world data for predicting the five-year survival of patients with EGFR-mutated NSCLC treated with EGFR-TKIs.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Chang Gung Memorial Hospital (Linkou Branch).
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
193P - Impact of coronavirus disease 2019 on patients with unresectable hepatocellular carcinoma treated with atezolizumab/bevacizumab
Presenter: Hongjae Chon
Session: Poster Display
Resources:
Abstract
194P - Real-world outcomes of cadonilimab (PD-1/CTLA-4 bispecific antibody) plus chemotherapy as first-line treatment in advanced gastric (G) or gastroesophageal junction (GEJ) cancer with PD-L1 CPS≤5
Presenter: Qi Xu
Session: Poster Display
Resources:
Abstract
195P - Ferroptosis signatures in pancreatic ductal adenocarcinomas and their role in patient survival: A translational unsupervised clustering analysis
Presenter: Quoc-Huy Trinh
Session: Poster Display
Resources:
Abstract
196P - Clinical significance of circulating CD8+ and CD4+ T cell proliferation in advanced gastric cancer receiving first-line chemotherapy
Presenter: In-Ho Kim
Session: Poster Display
Resources:
Abstract
197P - Treatment patterns and clinical outcomes of patients with unresectable advanced or metastatic (UAM) gastric/gastroesophageal junction adenocarcinoma (GA/GEJA) in China: A multicenter real-world study
Presenter: Yanqiao Zhang
Session: Poster Display
Resources:
Abstract
198P - Effectiveness of lenvatinib in patients with unresectable hepatocellular carcinoma: A multicenter observational study in Japan
Presenter: Namiki Izumi
Session: Poster Display
Resources:
Abstract
199P - Efficacy of endostar in combination with concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of esophagus: A randomized, open-label, phase II trial
Presenter: Yuexiao Qi
Session: Poster Display
Resources:
Abstract
200P - Prognosis of patients with hepatocellular carcinoma treated with transarterial chemoembolization: Development and validation of the ALFP score
Presenter: Baocuo Gong
Session: Poster Display
Resources:
Abstract
201P - A phase II study of serplulimab (a programmed death-1 inhibitor) with or without HLX04 (a bevacizumab biosimilar) for the treatment of advanced hepatocellular carcinoma
Presenter: Zhenggang Ren
Session: Poster Display
Resources:
Abstract
202P - Comparison of liver injury after transcatheter arterial chemoembolization and hepatic arterial infusion chemotherapy for intermediate and advanced hepatocellular carcinoma
Presenter: Yongru Chen
Session: Poster Display
Resources:
Abstract