Abstract 45P
Background
Pathologic complete response (pCR) is often utilized as a surrogate marker for overall survival in breast cancer. Significant differences in pCR rates are reported in many studies depending on the biological tumor profile and molecular classification. Based on our observations we hypothesize that few breast cancer patients are less likely to achieve pCR after neoadjuvant chemotherapy (NACT). The role of demographic variables in predicting pCR is still not clear. The aim of this study was to evaluate various demographic factors which could impact pCR rates.
Methods
A prospective analysis of 1246 patients with breast carcinoma who had undergone neoadjuvant chemotherapy (NACT) followed by surgery was done from June 2020 to December 2022. Demographic, surgical, and pathological data were collected on completion of therapy. Categorical variables were analyzed using χ2 or Fisher’s exact test and continuous data were analyzed using t-tests. Multiple linear regressions were used to study interactions between various demographic factors and pCR. Statistical analysis was done using SPSS v25.
Results
A total of 1324 patients were offered NACT, of which 1246 (94.1%) who underwent resection post-NACT were included in the analysis. Overall, 275 (22.1%) patients had pCR. 39 (14.2%) in ER+/HER2- group, 131 (47.6%) in HER2+ group; and 105 (38.2%) in ER-/HER2- group had pCR. Univariate analysis showed significant association between age <50 years, low body-mass index, and ability to achieve pCR. However, women with obesity had higher odds of residual disease (OR = 0.191 [0.029-1.157]; p=0.076). The results were consistent even after controlling for confounding variables such as grade, receptor status, and clinical T and N stages.
Conclusions
Younger age can predict a pCR and is an independent prognostic factor for locoregional recurrence in locally advanced breast cancer patients after NACT. Obesity is a risk factor for failure to achieve PCR in women undergoing NACT. The contrary was observed in non-obese patients as they had higher odds of achieving PCR. Studies with larger groups are needed to validate this observation. Further studies evaluating the role of BMI in drug resistance would be valuable.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.
Resources from the same session
102P - Enhancing colorectal cancer prevention in high-risk populations through faecal immunochemical test surveillance
Presenter: Li Xie
Session: Poster Display
Resources:
Abstract
103P - Anlotinib plus chemotherapy as first-line therapy for gastrointestinal tumor patients with unresectable liver metastasis: Updated results from a multi-cohort, multi-center phase II trial ALTER-G-001-cohort A
Presenter: Junwei Wu
Session: Poster Display
Resources:
Abstract
104P - The value of functional MR-imaging signature model for early prediction of chemotherapy response and its guidance for regimen adjustment to improve efficacy
Presenter: Wenhua Li
Session: Poster Display
Resources:
Abstract
105P - A single-arm, phase II, multicenter study of iparomlimab (QL1604) in patients (pts) with unresectable/metastatic deficient mismatch repair (dMMR)/microsatellite instability high (MSI-H) solid tumors
Presenter: Weijian Guo
Session: Poster Display
Resources:
Abstract
106P - Efficacy and safety of IBI351 (GFH925) monotherapy in metastatic colorectal cancer harboring KRASG12C mutation: Updated results from a pooled analysis of two phase I studies
Presenter: Ying Yuan
Session: Poster Display
Resources:
Abstract
107P - Tumor-stromal ratio in a new age fibroblast activated protein PET imaging as a biomarker for prediction of response to neoadjuvant chemoradiotherapy in carcinoma rectum
Presenter: swetha Suresh
Session: Poster Display
Resources:
Abstract
108P - Detection of HER2 overexpression in colorectal cancer: Comparison of a HANDLE classic NGS panel with standard IHC/FISH
Presenter: Lijuan Luan
Session: Poster Display
Resources:
Abstract
109P - Early onset metastatic colorectal cancer: Clinical-prognostic characteristics and correlation to molecular status
Presenter: Andrea Pretta
Session: Poster Display
Resources:
Abstract
110P - The correlation between multi-dimensional characteristics of circulating tumor cells (CTC) and treatment response in patients with initially unresectable metastatic colorectal cancer
Presenter: Yu Liu
Session: Poster Display
Resources:
Abstract
111P - Comparison of the efficacy and safety of fruquintinib and fruquintinib combined with immune checkpoint inhibitors in the treatment of metastatic microsatellite stable colorectal cancer: A real-world study
Presenter: Zhiqiang Wang
Session: Poster Display
Resources:
Abstract