Abstract 618P
Background
Renal Ewing’s sarcoma/primitive neuroectodermal tumor (ES/PNET) among adults is an extremely rare malignancy. Accurate diagnosis mandates detailed immunohistochemistry (IHC) and molecular characterization. There is limited data on the treatment of these patients. We present a clinicopathological and molecular profile of renal ES/PNET from a single South Indian tertiary referral center.
Methods
We conducted a retrospective study of adults with a histopathological diagnosis of renal ES/PNET treated at our center over the last 20 years. All patients had received a standard treatment protocol of VAC/IE. Principal outcomes were event-free survival (EFS), overall survival (OS) and adverse events during treatment.
Results
We included 25 patients with renal ES treated at our center from 2003-2023. 68% were male, with median age 29(18-53). 8(32%) had localised disease and 17(68%) had recurrent/metastatic disease; lung(36%) and bone(28%) were the common sites of metastases. Median tumour size was 13.5cm and renal vein/IVC thrombus was present in 11(55%) patients. IHC(done in 24 patients), showed CD99 +, NKX 2.2 + in 100% and FLI1 + in 93.7%. RT-PCR/FISH done in 15 patients revealed EWS-FLI1 translocations in 5 patients, 4 of which were Type 1. Nephrectomy was performed in 19 patients: 8 radical for non-metastatic and 11 palliative for metastatic disease. 16 received systemic therapy, the median number of cycles being 10(Range:2-16). 11 patients received concurrent radiation. Grade 3/4 anaemia, thrombocytopenia, neutropenia, and febrile neutropenia was seen in 1(6.6%),1(6.6%),8(50%) and 8(50%) patients respectively during VAC/IE. Only 50% of patients had long term follow up. Survival at 3 years is 64.3%(83% for localised disease, 57.3% for recurrent/metastatic).
Conclusions
This study represents a substantial cohort of adult patients with renal ES/PNET undergoing a unified treatment approach. Predominantly, tumors presented as extensive and locally aggressive with favourable survival for localised disease. While these observations offer valuable insights, the rarity of the disease underscores the need for larger, multicentric studies for more definitive conclusions.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
372P - Effectiveness of HAN-MI-RADS (head and neck molecular imaging-reporting and data system) criterion in head and neck squamous cell carcinoma post concurrent chemoradiotherapy
Presenter: Manoj Gupta
Session: Poster Display
Resources:
Abstract
373P - Investigating the impact of treatment on geriatric patients with locally advanced head and neck squamous cell carcinoma
Presenter: Yen Ting Liu
Session: Poster Display
Resources:
Abstract
374P - Immunohistochemical evaluation of oral lichen planus: A prospective clinical study
Presenter: Saravanan Sampoornam Pape
Session: Poster Display
Resources:
Abstract
375P - Survival and prognostic factors of head and neck squamous cell carcinoma patients treated with either definitive CCRT or post operative CCRT with platinum-based chemotherapy in Rajavithi hospital, Thailand
Presenter: wanit samadee
Session: Poster Display
Resources:
Abstract
376P - Nutrition as an independent prognostic factor in locally advanced nasopharyngeal carcinoma: A retrospective cohort study and propensity score-matched analysis
Presenter: haizhen yi
Session: Poster Display
Resources:
Abstract
377P - Oropharyngeal squamous cell carcinomas in Indian population: P16 positivity and treatment outcomes following chemoradiotherapy
Presenter: Parth Verma
Session: Poster Display
Resources:
Abstract
378P - A real-world retrospective analysis of the efficacy of pembrolizumab combined with chemotherapy as neoadjuvant treatment for locally advanced head and neck squamous cell carcinoma (LA HNSCC)
Presenter: zhu Liu
Session: Poster Display
Resources:
Abstract
379P - Nimotuzumab in combination with chemoradiation for patients with intermediate stage and locally advanced nasopharyngeal carcinoma: A retrospective comparative analysis using 5-year real-world survival data
Presenter: Andhika Rachman
Session: Poster Display
Resources:
Abstract
380P - An epidemiological analysis on the prevalence of oral cancer and its awareness among Irula tribes of South India
Presenter: Delfin Lovelina Francis
Session: Poster Display
Resources:
Abstract
381P - P16INK4 over-expression, early stages, keratinization, and surgical margin-free status are associated with better prognosis of oral squamous cell carcinoma (OSCC)
Presenter: Sumadi Lukman Anwar
Session: Poster Display
Resources:
Abstract