ESMO Asia Congress 2022

Abstract 118P

Background

Gastric cancer (GC) is a fourth leading cancer in Nepal and third most common cause for cancer-related mortality. This case-control study was carried out to find an association of behavioral and dietary factors in gastric cancer development among adult Nepali populations.

Methods

This study was conducted from Jan 2021 to Dec 2021 at Patan Academy of Health Sciences(PAHS), Lalitpur Nepal. In total, 89 patients with GC and 89 patients not having GC were studied as controls. Data were collected via face to face interview using a standard structured questionnaire, posing question about socio-demographic, behavioral and dietary habits, and clinical factors. Logistic regression method was used to calculate the odds ratio.

Results

The most common age group for both case and control was 55 to 65 years. The results showed that regular intake of red meat, duration of smoking, smokeless tobacco, fast food and fatty food, and family history of any type of cancer were directly associated with the risk of stomach cancer. On the contrary intake of chicken and vegetables, tea and coffee, regular walking and sports habit have inverse association with stomach cancer. Adjusted odds ratio shows, regular consumption of red meat have 2 times more risk (OR=2.0) of developing stomach cancer compare to irregular meat consumption. Moreover, person with history of H. pylori infection found 53% (OR=7.263; 95% CI; 3.614-14.597) more likely to develop stomach cancer.

Conclusions

Nepali studies on this topic are limited and more research is required to understand the etiology, need for development of suitable screening test, to demarcate high-risk population and to develop and evaluate the effect of primary prevention programs.