Abstract 18P
Background
High neutrophil to lymphocyte ratio may reflect the key role of systemic inflammation in enhancing angiogenesis, tumor growth and development of metastasis The role of lymphocytes cells in cancer control is exemplified by the strong association between high densities of tumor-infiltrating lymphocytes and better responses to both, cytotoxic treatments and outcome in patients with breast cancer.
Methods
A total number of files reviewed is 1167 files and a total of 102 breast cancer patients included in this study with histologically proven early stage (T1–2, N0–1, non-metastatic) breast cancer treated in Babylon Oncology Center from January 2009 to September 2014 were considered for this retrospective study. The following data were collected from patient file: age, date of diagnosis, date of recurrence and/or metastasis, follow up period, histological tumor type, tumor size, tumor-node-metastasis stage, expression of estrogen and/or progesterone receptor, HER-2-neu status, metastasis site and with inclusion criteria of Tumor stage up to stage IIA (T1-T2, N0/ T1, N1), follow up for at least 36 months and pre-treatment CBC with differential count.
Results
With mean age of 50.4 ± 11.7 years and minimum follow up 40 months, the overall median DFS was 62 months with 5 – years DFS of 52.5%, stage N0 show significant better DFS compared to stage N1 (P value 0.004), also patients with positive hormonal status show significant better DFS compared to negative hormonal status (P value 0.029), NLR has significant outcome on DFS when increased the ratio leading to declining in DFS (P value 0.006), NLR fair specificity (76.9%) with lower sensitivity (62.2%), with optimal cut point of > 2.194 to predict DFS with better DFS about 16 months (P value 0.0004), and Hazard Ration is 2.5 (P value 0.007), in univariate analysis the significant Hazard Ratio are NLR, N staging and Hormonal status while in multivariate analysis shows only NLR Hazard Ratio with (0.012 P value). In our study PLR neither sensitive nor specific with non-significant P value so it will not be consider as a prognostic index.
Conclusions
Elevated NLR is strongly associated with poor disease free survival of breast cancer patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Iraqi Board for Medical Specialities.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
75P - A parallel deep learning network framework for whole-body bone scan image analysis
Presenter: Xiaorong Pu
Session: Poster display session
Resources:
Abstract
76P - Perception and satisfaction of cancer patients in clinical trials
Presenter: Jukyung Jeon
Session: Poster display session
Resources:
Abstract
77P - A prognostic nomogram for the prediction of neuroblastoma
Presenter: Jian-Guo Zhou
Session: Poster display session
Resources:
Abstract
80P - The clinical usefulness of a new fat-dissociation method to detect lymph nodes from surgically resected specimen in colorectal cancer: Prospective randomized study
Presenter: Shiki Fujino
Session: Poster display session
Resources:
Abstract
81P - Concurrent or consolidation chemotherapy during radiation as neoadjuvant treatment for locally advanced rectal cancer: A propensity score analysis from two prospective study
Presenter: JianWei Zhang
Session: Poster display session
Resources:
Abstract
82P - Body mass index, tumour location, and colorectal cancer survival
Presenter: Dake Chu
Session: Poster display session
Resources:
Abstract
83P - Helicobacter bilis may play a role in the carcinogenesis of colitis associated colon cancer correlating to increased number of CD4+CD45RB+ T cells
Presenter: Xiangsheng Fu
Session: Poster display session
Resources:
Abstract
84P - Comprehensive evaluation of relapse risk (CERR) score for colorectal liver metastases development and validation
Presenter: Jianmin Xu
Session: Poster display session
Resources:
Abstract
85P - Which is the best partner for capecitabine-based neoadjuvant chemoradiotherapy in locally advanced rectal cancer? A retrospective analysis of a comprehensive cancer center
Presenter: Jingwen Wang
Session: Poster display session
Resources:
Abstract
87P - Negative to positive lymph node ratio-prognostic marker of survival in node positive rectal cancer
Presenter: Pavan Jonnada
Session: Poster display session
Resources:
Abstract