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Poster display session

166P - The comparison between UGT1A1 single heterozygous and wild type regarding the clinical outcomes of fixed dose irinotecan monotherapy for advanced gastric cancer: Multicenter retrospective study

Date

23 Nov 2019

Session

Poster display session

Topics

Tumour Site

Gastric Cancer

Presenters

Takahide Sasaki

Citation

Annals of Oncology (2019) 30 (suppl_9): ix42-ix67. 10.1093/annonc/mdz422

Authors

T. Sasaki1, S. Nakano2, S. Yuki3, K. Sawada4, T. Muranaka5, Y. Kawamoto6, H. Nakatsumi7, T. Ando8, H. Yoshita9, K. Harada10, Y. Kobayashi10, T. Miyagishima11, K. Hatanaka12, A. Tanimoto13, A. Ishiguro14, T. Honda15, M. Dazai16, Y. Komatsu17

Author affiliations

  • 1 Department Of Internal Medicine, Hokkaido Gastroenterology Hospital, 060-8638 - Sapporo/JP
  • 2 Department Of Gastroenterology And Hepatology, Hokkaido University Hospital, 065 - Sapporo/JP
  • 3 Gastroenterology And Hepatology Department, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 4 Gastrointestinal Oncology, National Cancer Center Hospital East Japan, 277-8577 - Chiba/JP
  • 5 Cancer Center Department, Municipal Wakkanai Hospital, 097-8555 - Wakkanai/JP
  • 6 Gastroenterology And Hepatology, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 7 Division Of Cancer Center, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 8 Department Of Gastroenterology And Hematology, Faculty Of Medicine, Toyama University Hospital, 930-0194 - Toyama/JP
  • 9 Department Of Gastroenterology And Hematology, Faculty Of Medcine, Toyama University Hospital, 930-0194 - Toyama/JP
  • 10 Department Of Medical Oncology, Kushiro Rosai Hospital, 085-8533 - Kushiro/JP
  • 11 Medical Oncology, Kushiro Rosai Hospital, 085-8533 - Kushiro/JP
  • 12 Department Of Gastroenterology, Hakodate Municipal Hospital, 041-8680 - Hakodate/JP
  • 13 Medical Oncology, Teine Keijinkai Hospital, 006-0811 - Sapporo/JP
  • 14 Medical Oncology, Teine Keijinkai Hospital, 006-8555 - Sapporo/JP
  • 15 Division Of Clinical Oncology Center, Nagaski University Hospital, 852-8501 - Nagasaki/JP
  • 16 Gastroenterology, Sapporo Medical Center NTT EC, 060-0061 - Sapporo/JP
  • 17 Cancer Center, Hokkaido University Hospital, 060-8638 - Sapporo/JP

Resources

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Abstract 166P

Background

Irinotecan is a key drug for advanced gastric cancer (AGC). We previously reported that patients with UGT1A1 single heterozygous (SH) had significantly high frequency of severe hematological adverse events (AEs) compared to patients with UGT1A1 wild type (WT) in irinotecan monotherapy for AGC. However, the difference of initial dose and relative dose intensity (RDI) of irinotecan between UGT1A1 WT and SH might affect those results. Therefore, we compared between UGT1A1 SH and WT regarding the clinical outcomes of the fixed dose irinotecan monotherapy for AGC.

Methods

We retrospectively analyzed the clinical data of patients who received initial fixed dose irinotecan (150mg/m2, bi-weekly) in the multi-institutional retrospective study. 100 eligible patients were registered from 8 centers in Japan.

Results

The number of patients with UGT1A1 WT/SH were 62 and 38, respectively. In WT/SH patients, performance status 0/1/≥2 was 20/40/2 and 11/23/4, treatment line 2nd/3rd or later was 27/35 and 18/20, HER2 positive/negative 17/45 and 8/30, respectively.In WT/SH patients, median PFS was 3.15 and 3.25 months (HR = 1.137, P = 0.543) and median OS was 10.4 and 7.3 months (HR = 0.734, P = 0.184). In WT/SH patients, dose reduction of Irinotecan was required in 30.6% and 50.0% (P = 0.053), delayed treatment due to AE was observed in 44.2% and 39.4% (P = 0.675), median treatment cycle was 6 and 4 (P = 0.278), and RDI was 0.86 vs 0.86(P = 0.864), respectively. Severe hematological AEs (≥G3) were 35.4% and 63.1%(P = 0.008) and severe non-hematological AEs (≥G3) were 6.5% and 15.8% (P = 0.173), respectively. Severe AEs in more than 5% patients were leukopenia (11.3% and 15.8%), neutropenia (14.5% and 31.6%), anemia (21.0% and 23.7%), and anorexia (1.6% and 10.5%).

Conclusions

UGT1A1 SH patients who received initial fixed dose Irinotecan had high frequency of severe hematological AE compared to WT patients. However, there was no significant difference in efficacy of Irinotecan monotherapy in each group.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Yoshito Komatsu.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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