Abstract 259P
Background
Borderline ovarian tumor(BOT) is a peculiar type of tumor with a favorable prognosis than the malignant tumors.There remains many gaps in our knowledge of the disease that result in controversies regarding their biology and different therapeutic approaches.The study aimed to evaluate the effect of suigical staging procedures on the prognosis and pregnant outcomes in the patients with BOTs.
Methods
We performed a retrospective analysis involving BOT patients who had underwent surgical staging procedures or not in West China Second University Hospital from January 2008 to January 2015 . The recurrence free survival (RFS)and pregnant outcomes were analysed using Kaplan-Meier method and Cox regression analysis, respectively.
Results
448 patients were included in the study with a median age of 35 years and median follow-up time of 113 months.Firty-two(11.6%)patients experienced relapse with the recurrent interval 80.2 months .Four(0.9%)patients died of the disease.118(26.3%)patients had undergone staging surgery while 330(73.7%) had done not.233 patients with fertility sparing surgery(FSS)attempted to conceive and 92(39.48%) achieved pregnancy.No significant difference of fertility outcomes were observed in the stagingsurgery or not groups(P = 0.691).In univariate analyses,staging surgery was obviously associated with RFS (HR = 2.191 P = 0.005),but was not an independent prognostic factor (p = 0.600) .Furthermore,the multivariate Cox analysis revealed that FIGO advanced stage(≥stage II), positive ascitescytologic washing and laparotomy were independent prognostic factors for RFS in the total population.
Conclusions
The BOT patients fail to benefit from surgical staging procedures in prognosis and fertility outcomes.When involved in early-stage (I),laproscope will be further rationally recommended to the patients with FSS than laparotomy.In addition, BOT patients with fertility desiring at advanced stage ,with invasive implants and bilateral tumors should choose FSS carefully.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
West China Second University Hospital,SiChuan Univeristy.
Funding
Has not received any funding.
All authors have declared no conflicts of interest.
Resources from the same session
237P - PARP inhibitor in platinum resistant ovarian cancer: Single center real world experience
Presenter: Saphalta Baghmar
Session: Poster display session
Resources:
Abstract
238P - Laparoscopic cytoreduction in low disease burden, advanced-stage ovarian cancers: Experience from a tertiary cancer center
Presenter: Vikas Gupta
Session: Poster display session
Resources:
Abstract
239P - Impact of counseling on patient reported sexual adjustment following chemoradiation and brachytherapy for cervical cancer
Presenter: Vibhay Pareek
Session: Poster display session
Resources:
Abstract
240P - Morbidity and mortality of cervical cancer in the Republic of Kazakhstan
Presenter: Almagul Zhabagina
Session: Poster display session
Resources:
Abstract
241P - Impact of genomic alterations and HPV genotypes on clinical outcomes of Japanese patients with locally advanced cervical cancer
Presenter: Ikumi Kuno
Session: Poster display session
Resources:
Abstract
242P - Impact of combined interstitial and intracavitary brachytherapy in locally advanced cervical cancer: A survival and toxicity profile assessment
Presenter: Vibhay Pareek
Session: Poster display session
Resources:
Abstract
243P - Cervical cancer screening in sub-urban area of Banten and factor associated with uptake of screening
Presenter: Prio Wibisono
Session: Poster display session
Resources:
Abstract
245P - Factors influencing adherence to cryotherapy following positive VIA result as cervical cancer prevention in Temanggung, Central Java, Indonesia
Presenter: Herindita Puspitaningtyas
Session: Poster display session
Resources:
Abstract
246P - The main of reasons of advanced stage cervical cancer in Uzbekistan
Presenter: Zakhirova Nargiza
Session: Poster display session
Resources:
Abstract
247P - Role of ADC values in assessing response after chemoradiotherapy in cervix cancer and in identifying residual disease
Presenter: Venkata Pradeep Babu Koyyala
Session: Poster display session
Resources:
Abstract