Abstract 259P
Background
Borderline ovarian tumor(BOT) is a peculiar type of tumor with a favorable prognosis than the malignant tumors.There remains many gaps in our knowledge of the disease that result in controversies regarding their biology and different therapeutic approaches.The study aimed to evaluate the effect of suigical staging procedures on the prognosis and pregnant outcomes in the patients with BOTs.
Methods
We performed a retrospective analysis involving BOT patients who had underwent surgical staging procedures or not in West China Second University Hospital from January 2008 to January 2015 . The recurrence free survival (RFS)and pregnant outcomes were analysed using Kaplan-Meier method and Cox regression analysis, respectively.
Results
448 patients were included in the study with a median age of 35 years and median follow-up time of 113 months.Firty-two(11.6%)patients experienced relapse with the recurrent interval 80.2 months .Four(0.9%)patients died of the disease.118(26.3%)patients had undergone staging surgery while 330(73.7%) had done not.233 patients with fertility sparing surgery(FSS)attempted to conceive and 92(39.48%) achieved pregnancy.No significant difference of fertility outcomes were observed in the stagingsurgery or not groups(P = 0.691).In univariate analyses,staging surgery was obviously associated with RFS (HR = 2.191 P = 0.005),but was not an independent prognostic factor (p = 0.600) .Furthermore,the multivariate Cox analysis revealed that FIGO advanced stage(≥stage II), positive ascitescytologic washing and laparotomy were independent prognostic factors for RFS in the total population.
Conclusions
The BOT patients fail to benefit from surgical staging procedures in prognosis and fertility outcomes.When involved in early-stage (I),laproscope will be further rationally recommended to the patients with FSS than laparotomy.In addition, BOT patients with fertility desiring at advanced stage ,with invasive implants and bilateral tumors should choose FSS carefully.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
West China Second University Hospital,SiChuan Univeristy.
Funding
Has not received any funding.
All authors have declared no conflicts of interest.
Resources from the same session
133P - Prognostic and predictive factors from the phase III CELESTIAL trial of cabozantinib (C) versus placebo (P) in previously treated advanced hepatocellular carcinoma (aHCC)
Presenter: Thomas Yau
Session: Poster display session
Resources:
Abstract
134P - Identification, development and validation of a circulating miRNA-based diagnostic signature for early detection of gastric cancer
Presenter: Daisuke Izumi
Session: Poster display session
Resources:
Abstract
135P - The promising key genes associated with tumour microenvironment and prognosis of hepatocellular carcinoma
Presenter: Jing Fang
Session: Poster display session
Resources:
Abstract
136P - Helicobacter pylori-positive gastric diffuse large B-cell lymphoma: A subset with distinct prognostic features
Presenter: Yuan Cheng
Session: Poster display session
Resources:
Abstract
137P - Significant benefit of pyrotinib combined with SHR6390 in patients with multiline-resistant HER2-positive advanced gastric cancer
Presenter: Zuhua Chen
Session: Poster display session
Resources:
Abstract
138P - Incidence of supracarinal lymph node positivity in operated cases of total esophagectomy: Short term results from a tertiary cancer centre
Presenter: Akhil Palod
Session: Poster display session
Resources:
Abstract
139P - Prognostic usefulness of advanced lung cancer inflammation index in locally-advanced pancreatic carcinoma patients treated with radical chemoradiotherapy
Presenter: Ayberk Besen
Session: Poster display session
Resources:
Abstract
140P - Pancreaticoduodenectomy versus combined neoadjuvant chemotherapy and pancreaticoduodenectomy: Survival patterns among patients with stage II & III periampullary carcinoma
Presenter: Mai Abdelkader
Session: Poster display session
Resources:
Abstract
141P - A 13-gene signature of DNA repair predicts prognosis in gastric cancer patients
Presenter: Jinjia Chang
Session: Poster display session
Resources:
Abstract
142P - Relation between Interleukin -4 (590C/T) gene polymorphism and hepatocellular carcinoma risk in HBV and HCV patients
Presenter: Suzy Gohar
Session: Poster display session
Resources:
Abstract