Abstract 530P
Background
Recent evidence have showed that high level of systemic inflammation is associated with poor survival in patients with malignancy by promoting cell proliferation. Inflammation-based serum biomarkers including C Reactive Protein (CRP), Albumin (ALB) and CRP/ALB ratio have been showed to have prognostic value in patients with Small Cell Lung Cancer (SCLC). C-reactive protein (CRP) is a nonspecific serum marker of acute-phase inflammatory response. Studies have hypothesized that High CRP is a surrogate marker of tissue inflammation secondary to tumor growth. Albumin is both an inflammatory and nutritional marker. They are readily available and cost-effective tests that are potential prognostic biomarkers and therapeutic targets. Prognostic biomarkers help to optimize therapy decisions, as they provide information on the likelihood of response to a given chemotherapeutic regimen.
Methods
The databases of PubMed, Cochrane, and Google Scholar were systematically searched until July 2019. Associations between CRP, ALB and CRP/ALB ratio and overall survival (OS) were investigated by pooling hazard ratio (HR) and 95% confidence interval (CI).
Results
A total of 13 studies comprising of 2,034 patients were included. The results showed that only High CRP (HR 1.36, CI 95% 1.01, 1.82 p = 0.04) and High CRP/ALB (HR 1.38, CI 9%% 1.15, 1.64 p = 0.0004) ratio are significantly associated with overall survival. Albumin has no statistical association with OS.
Conclusions
High CRP and CRP/ALB ratio are independent prognostic biomarkers in patients with SCLC.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
357P - Application of multi-modal approach to palliation in end of life head and neck cancer pain
Presenter: Srujana Joga
Session: Poster display session
Resources:
Abstract
358P - Evaluation of continuous low dose versus standard dose capecitabine monotherapy as second/third-line chemotherapy for metastatic malignancies
Presenter: Swaroop Revannasiddaiah
Session: Poster display session
Resources:
Abstract
359P - Factors associated with economic burden among cancer patients with minor children: A cross-sectional web-based survey of an online cancer community
Presenter: Midori Yuki
Session: Poster display session
Resources:
Abstract
360P - Factors influencing treatment decisions among breast cancer patients in the Philippine general hospital cancer institute: Medical oncology outpatient clinic
Presenter: Bobby De Guzman
Session: Poster display session
Resources:
Abstract
361P - The role of volunteers in quality palliative care delivery
Presenter: NABANITA MANDAL
Session: Poster display session
Resources:
Abstract
362P - Survey to assess the efficacy of continuity of care delivered through an out of hours telephonic consultation liaison
Presenter: Rahul D. Arora
Session: Poster display session
Resources:
Abstract
366P - Activity of larotrectinib in TRK fusion cancer patients with primary central nervous system tumours
Presenter: David Ziegler
Session: Poster display session
Resources:
Abstract
367P - Molecular characteristics and efficacy of crizotinib among different subsets of MET Amplification detected by next-generation sequencing in lung cancer
Presenter: Jing Li
Session: Poster display session
Resources:
Abstract
368P - Genomic analysis of malaysian breast cancers unravel molecular differences from Caucasian breast cancers
Presenter: Soo-Hwang Teo
Session: Poster display session
Resources:
Abstract
369P - Institutional-based prospective molecular profiling of advanced solid tumours in Hong Kong: A report of 253 cases
Presenter: Herbert Loong
Session: Poster display session
Resources:
Abstract