Abstract 10P
Background
There remains uncertainty regarding prognosis and treatment effect in small, node negative breast cancer. We described overall prognosis of small (<1cm), node (-), HER2 (+) breast cancer after curative surgery, and effect of adjuvant treatment. There remains uncertainty regarding prognosis and treatment effect in small, node negative breast cancer. We described overall prognosis of small (<1cm), node (-), HER2 (+) breast cancer after curative surgery, and effect of adjuvant treatment.
Methods
We identified patients who fulfilled inclusion criteria (curative surgery, <1cm, N0, and HER2(+) breast cancer) by medical chart review. We collected data of baseline characteristics, receptor status, surgical method, histologic type, histologic and nuclear grade, adjuvant treatment (chemotherapy, radiotherapy, endocrine therapy, and trastuzumab. We compared baseline characteristics between patients with or without adjuvant treatment (Chi-square), and the prognosis between them (Kaplan meier curve and log-rank test). SPSS version 18.0 was used for statistical analysis.
Results
A total of 429 patients (pT1a=205, pT1b=222) were identified. In patients with pT1a, only 1 patient experienced systemic recurrence and death. No difference was observed in DFS and OS between patients with adjuvant chemotherapy and/or adjuvant trastuzumab. In pT1b, HR(-) patients (N = 52), longer DFS was observed in patients who received adjuvant chemotherapy (p = 0.013). There was no difference in DFS according to trastuzumab treatment (p = 0.441). No difference was found according to adjuvant treatment in overall or HR(+) pT1b patients.
Conclusions
In conclusion, our result showed overall prognosis of small(<1cm), node (-), and HER2+ breast cancer and patients with pT1b and HR(-) patients can benefit from adjuvant chemotherapy. Subsequent study with large sample size is warranted.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
458P - Mutation tracking in circulating tumour DNA predicts relapse in completely resected EGFR-mutated NSCLC
Presenter: Martin Filipits
Session: Poster display session
Resources:
Abstract
460P - Mendelian randomization study showed no causality between metformin use and lung cancer risk
Presenter: Jiayi Shen
Session: Poster display session
Resources:
Abstract
461P - Blood trace minerals and lung cancer: A Mendelian randomization study
Presenter: Wei Xian
Session: Poster display session
Resources:
Abstract
463P - Prediction of invasiveness in lung adenocarcinoma using machine learning algorithm based on 3D-CT imaging
Presenter: Yusuke Saeki
Session: Poster display session
Resources:
Abstract
459P - Fish intake, dietary polyunsaturated fatty acids, and lung cancer: systematic review and dose-response meta-analysis of 1.7 million men and women
Presenter: Chao Cao
Session: Poster display session
Resources:
Abstract
462P - Usefulness for prevention of postoperative cerebrovascular complications in patients with lung cancer using carotid ultrasonography
Presenter: Sadanori Takeo
Session: Poster display session
Resources:
Abstract
468P - Histological type analysis of 10-year follow-up of WJTOG0105: A phase III study comparing second- and third-generation regimens with concurrent thoracic radiotherapy in unresectable stage III non-small cell lung cancer
Presenter: Masahiro Tsuboi
Session: Poster display session
Resources:
Abstract
469P - Comparison of combined chemoradiotherapy regimens; Paclitaxel plus carboplatin and cisplatin plus etoposide for locally advanced non-small cell lung cancer: A randomised phase III trial
Presenter: Alper Ata
Session: Poster display session
Resources:
Abstract
472P - Integration of expression rate and absolute cell counts of PD-1+ stromal tumour-infiltrating lymphocytes: Prognostic significance in esophageal squamous cell carcinoma
Presenter: Qingkun Song
Session: Poster display session
Resources:
Abstract
467P - The free-circulating mtDNA copies number in plasma of patients with NSCLC
Presenter: Olga Bulgakova
Session: Poster display session
Resources:
Abstract