227O - Laparoscopic radical hysterectomy leads to poorer prognosis compared with abdominal radical hysterectomy in patients with locally advanced cervical cancer

Background

This study aimed to explore the survival outcomes of early-stage cervical CC patients treated with laparoscopic/abdominal radical hysterectomy (LRH/ARH).

Methods

We performed a retrospective analysis involving women who had underwent LRH/ARH for CC in early stage during the 2013–2015 period in West China Second University Hospital. The survival outcomes and potential prognostic factors were evaluated using Kaplan-Meier method and Cox regression analysis, respectively.

Results

A total of 678 patients were included in our analysis. The overall survival (OS) and progression-free survival (PFS) between the ARH (n = 423) and LRH (n = 255) groups achieved no significant differences (p = 0.122, 0.285, respectively). However, in the patients with locally advanced CC (LACC), the OS of LRH group was significantly shorter than that of ARH group (p = 0.017). Conversely, in patients with a tumor diameter ≤4 cm, the LRH group had a significantly longer OS than the ARH group (p = 0.013). The multivariate Cox analysis revealed that FIGO stage, histology, parametrial invasion and pelvic lymph node invasion were independent prognostic factors for OS and PFS, whereas surgical method was not a statistically significant predictor of OS (p = 0.806) or PFS (p = 0.236) in CC patients.

Conclusions

LRH was associated with poorer prognosis compared with ARH in LACC. Priority should be given to ARH for the surgical treatment of patients with LACC.

Clinical trial identification

Editorial acknowledgement

This study was undertaken after approved by the ethics committee of West China Second University Hospital.

Legal entity responsible for the study

West China Second University Hospital.

Funding

Sichuan Youth Foundation of Science of Technology.

Disclosure

The author has declared no conflicts of interest.