Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

195P - HGCSG1601: A retrospective cohort study of the efficacy and safety of nab-paclitaxel plus gemcitabine (nab-P+GEM) for unresectable locally advanced pancreatic cancer (LAPC)


23 Nov 2019


Poster display session


Tumour Site

Pancreatic Adenocarcinoma


Aya Tanimoto


Annals of Oncology (2019) 30 (suppl_9): ix42-ix67. 10.1093/annonc/mdz422


A. Tanimoto1, M. Yagisawa2, S. Nakano3, Y. Kawamoto4, S. Yuki5, A. Ishiguro6, T. Takahata7, A. Sato7, I. Iwanaga8, N. Ehira8, M. Uebayashi8, O. Muto9, T. Sasaki10, K. Hatanaka11, M. Tateyama12, T. Wakabayashi13, M. Dazai14, S. Minami15, Y. Sakata16, Y. Komatsu17

Author affiliations

  • 1 Medical Oncology, Teine Keijinkai Hospital, 006-0811 - Sapporo/JP
  • 2 Gastroenterology, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 3 Department Of Gastroenterology And Hepatology, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 4 Gastroenterology And Hepatology, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 5 Gastroenterology And Hepatology Department, Hokkaido University Hospital, 060-8638 - Sapporo/JP
  • 6 Medical Oncology, Teine Keijinkai Hospital, 006-8555 - Sapporo/JP
  • 7 Medical Oncology, Hirosaki University Graduate School of Medicine, 036-8562 - Hirosaki/JP
  • 8 Medical Oncology, Kitami Red Cross Hospital, 090-8666 - Kitami/JP
  • 9 Medical Oncology, Japanese Red Cross Akita Hospital, 010-1495 - Akita/JP
  • 10 Internal Medicine, Hokkaido Gastroenterology Hospital, 065-0041 - Sapporo/JP
  • 11 Gastroenterology, Hakodate Municipal Hospital, 041-8680 - Hakodate/JP
  • 12 Internal Medicine, Tomakomai Nisshou Hospital, 053-0803 - Tomakomai/JP
  • 13 Surgery, Akita City Hospital, 010-0933 - Akita/JP
  • 14 Gastroenterology, Sapporo Medical Center NTT EC, 060-0061 - Sapporo/JP
  • 15 Gastroenterology, Oji General Hospital, 053-8506 - Tomakomai/JP
  • 16 Medical Oncology, Misawa City Hospital, 033-0022 - Misawa/JP
  • 17 Cancer Center, Hokkaido University Hospital, 060-8638 - Sapporo/JP


Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract 195P


The regimens of nab-P+GEM have become available for advanced pancreatic cancer, especially metastatic disease. However, there are not enough data of nab-P+GEM for LAPC.


This is a retrospective multiple institutes cohort study using medical records of LAPC patients who received nab-P+GEM between January 2015 and September 2017. We have surveyed their characteristics and treatment outcomes.


The number of relevant patients was 48 at 11 institutes. Median age was 68 years old, male/female : 22/26, ECOG PS 0/1/2 : 33/13/2, primary site; head/body/tail : 28/18/2. Relative dose intensity was nab-P; 0.588 (0.065-1.012) and GEM; 0.656 (0.368-1.012). Response rate was 27.0% and Disease control rate was 94.6% among patients who had target lesion. Median progression-free survival was 9.4 months (95% CI, 5.4 – 13.4) and median overall survival was 19.6 months (95% CI, 13.9 – 24.3). The most common adverse event of grade 3 or higher was neutropenia (61.7%). Febrile neutropenia was 8.3%.


It seemed that nab-P+GEM was effective for patients with LAPC. Prospective and further investigation in more cases is expected.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Hokkaido Gastrointestinal Cancer Study Group.


Has not received any funding.


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.