YO16 - Clear cell RCC with synchronous metastasis at transplanted kidney and bone in patient post Cadaveric donor kidney transplantation

Case summary

Thai male patient, 58 years old

He had been diagnosed essential hypertension and dyslipidemia for over 10 years (2005) and received cadaveric donor kidney transplantation on Oct 2005.

In May 2017, he presented with left hip closed fracture, in plain film of Lt hip had showed osteolytic lesion at left head and neck of femur with fracture at intertrochanter of femur.

He received bone biopsy and result showed metastatic clear cell renal cell carcinoma.

On CT chest and whole abdomen include pelvis had seen heterogeneous enhancing mass at right native kidney size 7.1 x 7.2 x 8.5 cm with synchronous lesion at transplanted kidney size 1.1 x 1.4 cm and pathological lymph nodes at internal iliac artery, no distance metastasis.

He underwent surgery to debulk tumor and hemiarthroplasty of left hip and received post-operative radiotherapy. Post-operative, he had been added everolimus 0.5 mg per day.

He starts treatment with Pazopanib since June 2007 until now and has hand foot syndrome grade I, diarrhea grade I, his blood pressure is well controlled and now he still has partial response.

Clinical trial identification

Editorial acknowledgement