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Poster display session

49P - Biochemical study on modifying role of variants of leptin gene and its receptor on serum leptin levels in breast cancer


23 Nov 2019


Poster display session


Tumour Site

Breast Cancer


Alshimaa Alhanafy


Annals of Oncology (2019) 30 (suppl_9): ix13-ix19. 10.1093/annonc/mdz418


A.M. Alhanafy1, S. Tayel2, S. Ahmed3, A. Altorgoman3, I. Elsayed3

Author affiliations

  • 1 Clinical Oncology And Nuclear Medicine, Faculty of Medicine - Menoufia University, 32511 - sheben elkom/EG
  • 2 Medical Biochemistry And Molecular Biology, Faculty of Medicine - Menoufia University, 32511 - sheben elkom/EG
  • 3 Chemistry Department, Faculty of Science - Menoufia University, 32511 - sheben elkom/EG


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Abstract 49P


Leptin is produced by adipose tissue of breast and is overexpressed in Breast cancer. Association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with Breast cancer are inconsistent. Only a very few studies have examined this biochemical and genetic variables so we planned to investigate this association and its impact on leptin level and disease characteristics.


Study included 70 females (40 women with pathological prove of invasive Breast cancer patients and 30 controls). Staging was done according to the American Joint Committee on Cancer 8th edition. LEP and LEPR polymorphisms were estimated by real time PCR. Serum leptin was measured by ELISA.


Both LEPR rs 1137101 and LEP rs 7799039 increase risk of breast cancer where GG genotype and G allele frequencies of LEPR rs 1137101 were significantly higher in patients than control [52.5% vs 16.7% and 68.8% vs 36.7%] (p = 0.002) and (p < 0.001) respectively. GG genotype increase risk of BC with [OR 9.1: 95% CI 2.30-35.94] while G allele predispose to disease with [OR 3.8: 95% CI 1.87 – 7.70]. Furthermore, LEP rs 7799039 A allele was markedly elevated in patients (61.2%) than healthy ones (43.3%) (p = 0.037) with [OR 2.06: 95% CI 1.05 – 4.08]. Leptin levels were markedly elevated than healthy ones (p < 0.001).


Results clarified interesting relation of circulating leptin level and LEP and LEPR polymorphisms with predicting Breast cancer that may be implicated in pathogenesis of disease.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Menoufia University.


Has not received any funding.


All authors have declared no conflicts of interest.

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