Abstract 251P
Background
Uterine leiomyoma (UL) is the most common female pelvic benign tumor with recurrence rates of 16.7%-52.8%. We aimed to propose a prognostic index (PI) model for predicting the long-term (>5 years) risk of UL recurrence.
Methods
Women aged 18–44 years who initially underwent myomectomy for UL at one of the three study hospitals between April 2012 and October 2013 were enrolled. The data collected included patients’ demographics, leiomyomas’ characteristics, relapses, subsequent contraceptive methods, and postoperative gravidity and parity. A PI model was proposed based on the β-coefficients in the results of multivariate Cox regression analysis in prediction model group. The differences among the PI-based risk groups were tested by Kaplan–Meier analysis (using paired log-rank test) and univariate Cox regression analysis (using the Forward: LR) in prediction model, internal validation and external validation group.
Results
There were 725 patients included in this study. PI formula =1.5(if 3-5 leiomyomas)+2(if > 5 leiomyomas)+1(if residue)+1(if not submucosal)+1(if combined endometriosis). The PI value (0-5) was divided into low-risk group, intermediate-risk group, and high-risk group by cut-off values 1.25 and 3.75. In the prediction model group, the high-risk group had a significantly 4.55 times greater recurrence risk of UL than that in the low-risk group [cumulative recurrence rate (CR): 82.1% vs 29.5%, HR = 4.55, 95% CI; 2.821-7.339]; the intermediate-risk group had a significantly 2.81 times greater recurrence risk of UL than that in the low-risk group (CR: 62.3% vs 29.5%, HR = 2.81, 95% CI; 2.035-3.878). The differences between any two risk groups were also statistically significant (P < 0.05) in both internal and external validation groups.
Conclusions
The PI model was proved to be effective in distinguishing low-risk, intermediate-risk, and high-risk groups for long-term recurrence of UL after initial myomectomy in women aged 18-44 years, allowing it to be an objective tool aid in clinical decision making. In the future, prospective researches should be carried out to confirm the predictive ability of this PI model, and its practical value in clinical decision making.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Zheng Yu Li.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
504P - A single center report for safety and efficacy of CT-707 in Chinese patients with advanced, anaplastic lymphoma kinase-rearranged non-small cell lung cancer or other tumours
Presenter: Peng Song
Session: Poster display session
Resources:
Abstract
519P - Initial results of lung cancer genomic screening project for individualized medicine in Asia: LC-SCRUM-Asia
Presenter: Chih-Hsi Kuo
Session: Poster display session
Resources:
Abstract
521P - A randomized, phase II study comparing irinotecan versus amrubicin as maintenance therapy after first-line induction therapy for extensive disease small cell lung cancer (HOT1401/NJLCG1401)
Presenter: Keisuke Baba
Session: Poster display session
Resources:
Abstract
526P - A phase II study of apatinib in patients with recurrent/metastatic esophageal squamous cell carcinoma (ESCC)
Presenter: Li Chu
Session: Poster display session
Resources:
Abstract
499P - Prevalence of uncommon epidermal growth factor receptor (EGFR) alterations detected by circulating tumour DNA (ctDNA) in non-small cell lung cancer (NSCLC) patients in Hong Kong
Presenter: Oscar Siu Hong Chan
Session: Poster display session
Resources:
Abstract
489P - Overall survival in patients with EGFRm+ NSCLC receiving sequential afatinib and osimertinib: Updated analysis of the GioTag study
Presenter: Maximilian J. Hochmair
Session: Poster display session
Resources:
Abstract
509P - Second-line treatment after first-line vinorelbine in advanced platinum unfit NSCLC patients: An exploratory analysis of randomized Tempo-Lung trial
Presenter: Andrea Camerini
Session: Poster display session
Resources:
Abstract
500P - Clinico-molecular characteristics of Chinese primary non-small cell lung cancer patients with compound EGFR mutations
Presenter: Jianchun Duan
Session: Poster display session
Resources:
Abstract
527P - A multicenter study of NRG1 fusions in Chinese non-small cell lung cancer patients and response to afatinib using next generation sequencing
Presenter: Xingliang Li
Session: Poster display session
Resources:
Abstract
481P - Updated survival outcomes of the phase II study of low starting dose of afatinib as first-line treatment in patients with EGFR mutation-positive non-small cell lung cancer (KTORG1402)
Presenter: Toshihide Yokoyama
Session: Poster display session
Resources:
Abstract