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General Recommendations

Hyperpigmentation usually occurs secondary to unprotected sun exposure or to inflammation of the skin (eg by acneiform eruption or eczema). Therefore, adequate treatment of acneiform eruption or eczema is recommended along with sun protection.1


Avoid sun exposure during the middle of the day, use the morning and the late afternoons for outdoor activities. Use a sun protection cream of SPF 20 or higher.


  • Sun cream of SPF 20 or higher on exposed skin areas, applied in the morning and then reapplied every 2-3 hours during exposure to the sun.

EGFRI Treatment

Continue with the selected EGFRI-treatment regimen. Continue with/withold the selected EGFRI-treatment regimen, as recommended in the current and relevant SmPC and according to the patient’s condition.2,3,4,5,6


1Segaert S & Van Cutsem E. Ann Oncol 2005; 16: 1425-1433.
2European Medicine Agency. Tarceva® (erlotinib) Summary of Product Characteristics 2009.
3European Medicine Agency. Iressa® (gefitinib) Summary of Product Characteristics 2009.
4European Medicine Agency. Erbitux® (cetuximab) Summary of Product Characteristics 2009.
5European Medicine Agency. Vectibix® (panitumumab) Summary of Product Characteristics 2009.
6European Medicine Agency. Tyverb® (lapatinib) Summary of Product Characteristics 2010.

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