Applications in NTRK Gene Fusion Testing
RT-PCR can confirm the presence of an NTRK gene fusion detected by another technique, such as IHC which detects TRK protein expression . Importantly, RT-PCR does not provide information on the other fusion partner found in novel NTRK gene fusions.
- Doebele RC, Davis LE, Vaishnavi A et al. An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov 2015; 5: 1049-1057.