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Applications in NTRK Gene Fusion Testing

RT-PCR can confirm the presence of an NTRK gene fusion detected by another technique, such as IHC which detects TRK protein expression [1]. Importantly, RT-PCR does not provide information on the other fusion partner found in novel NTRK gene fusions.

References

  1. Doebele RC, Davis LE, Vaishnavi A et al. An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov 2015; 5: 1049-1057.

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