Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+, Mozilla Firefox 20+, Internet Explorer 11, Opera 15–18, Apple Safari 7, SeaMonkey 2.15-2.23

Become a member
  1. OncologyPRO
  2. Oncology in Practice
  3. Anti-Cancer Agents and Biological Therapy
  4. Targeting NTRK Gene Fusions
  5. Importance of Testing Cancers for NTRK Gene Fusions
  6. General Challenges of Testing for Cancers With NTRK Gene Fusion
  7. Other Techniques
  8. Liquid Biopsy

Liquid Biopsy

Previous Page Next Page

Disadvantages

In certain circumstances, liquid biopsies may not be as sensitive as IHC or FISH for testing NTRK gene fusions [1, 3]. If circulating DNA and RNA volume is low (e.g., when the tumour volume is low), a test failure or false negative may result. However, enrichment methods (e.g., hybrid capture, etc.) may be used to increase detection [4].

References

  1. Hofman P. Liquid Biopsy and Therapeutic Targets: Present and Future Issues in Thoracic Oncology. Cancers (Basel) 2017; 9: pii: E154. doi: 110.3390/cancers9110154.
  2. Merker JD, Oxnard GR, Compton C et al. Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review. J Clin Oncol 2018; 36: 1631-1641.

  3. Hechtman JF. NTRK insights: best practices for pathologists. Mod Pathol. 2022; 35(3):298-305.

  4. Bruno R, Fontanini G. Next Generation Sequencing for Gene Fusion Analysis in Lung Cancer: A Literature Review. Diagnostics (Basel). 2020 Jul 27;10(8):521.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings

  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.