Advantages
The advantages of DNA-based NGS are those common to all NGS techniques as well as those specific to the DNA-based NGS. The advantages of DNA-based NGS are summarised in the following table.
Advantages of DNA-based NGS for Testing for NTRK Gene Fusions
Advantages |
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References
- Cocco E, Scaltriti M, Drilon A. NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol 2018; 15: 731-747.
- Abel HJ, Al-Kateb H, Cottrell CE et al. Detection of gene rearrangements in targeted clinical next-generation sequencing. J Mol Diagn 2014; 16: 405-417.
- Zehir A, Benayed R, Shah RH et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med 2017; 23: 703-713.
- Beadling C, Wald AI, Warrick A et al. A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing. J Mol Diagn 2016; 18: 165-175.