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The disadvantages of FISH for detecting NTRK gene fusions are summarised in the following table.

Table 27: Disadvantages of FISH for Testing for NTRK Gene Fusions


  • Multiple tests are required as most commercial labs perform single gene, break-apart FISH
  • DNA level rearrangements are not confirmed to be transcribed (RNA) or expressed (protein) fusions (e.g. may detect ‘passenger’ alterations)
  • Requiresthat the target gene is known

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