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  1. OncologyPRO
  2. Oncology in Practice
  3. Anti-Cancer Agents and Biological Therapy
  4. Targeting NTRK Gene Fusions
  5. Importance of Testing Cancers for NTRK Gene Fusions
  6. General Challenges of Testing for Cancers With NTRK Gene Fusion
  7. Fluorescence In Situ Hybridisation (FISH)

Fluorescence In Situ Hybridisation

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Disadvantages

The disadvantages of FISH for detecting NTRK gene fusions are summarised in the following table.

Disadvantages of FISH for Testing for NTRK Gene Fusions

Disadvantages

  • Multiple tests are required as most commercial labs perform single gene, break-apart FISH
  • DNA level rearrangements are not confirmed to be transcribed (RNA) or expressed (protein) fusions (e.g. may detect ‘passenger’ alterations)
  • Requires that the target gene is known

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